Akhtar N, Verma K K, Sharma A
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Eur Ann Allergy Clin Immunol. 2018 Mar;50(2):59-65. doi: 10.23822/EurAnnACI.1764-1489.40. Epub 2017 Nov 27.
Parthenium dermatitis is a chronic immuno-inflammatory, distressing skin disease and is mediated by activated T-lymphocyte which is primarily manifested on the exposed sites of the face, neck, hand and flexures. Parthenium hysterophorus is ubiquitous, hence it is diffi-cult to avoid the aero-allergenic antigen parthenin, responsible for the contact dermatitis. The pathogenesis of parthenium dermatitis is characterized by infiltration of T-lymphocytes into challenged skin sites and the development of a cutaneous inflammation due to altered regulatory network of pro and anti-inflammatory cytokines. Regulation of inflammatory events perpetuated by cytokines continues to complicate efforts to analyze both the function of individual cytokine and the influence of candidate gene polymorphism on expression and disease severity. The genetic polymorphisms in these cytokines are significantly affecting immunological parameters and, subsequently, modulation and polarization of immune responses. This review has focused mainly on understanding of the mechanisms of genetic susceptibility of cytokine genes in this disease and, further, this process is likely to achieve significant advances in the diagnosis and management of parthenium dermatitis.
银胶菊皮炎是一种慢性免疫炎症性、令人痛苦的皮肤病，由活化的T淋巴细胞介导，主要表现在面部、颈部、手部和屈侧等暴露部位。银胶菊随处可见，因此难以避免引发接触性皮炎的空气变应原性抗原银胶素。银胶菊皮炎的发病机制表现为T淋巴细胞浸润到受刺激的皮肤部位，并由于促炎和抗炎细胞因子调节网络的改变而引发皮肤炎症。细胞因子持续引发的炎症事件的调节，继续使分析单个细胞因子的功能以及候选基因多态性对表达和疾病严重程度的影响变得复杂。这些细胞因子中的基因多态性显著影响免疫参数，进而影响免疫反应的调节和极化。本综述主要关注对该疾病中细胞因子基因遗传易感性机制的理解，此外，这一过程可能会在银胶菊皮炎的诊断和管理方面取得重大进展。
