Aalto-Setälä Laura, Uppstu Peter, Sinitsyna Polina, Lindfors Nina C, Hupa Leena
Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Henrikinkatu 2, 20500 Turku, Finland.
Polymer Technology Research Group, Faculty of Science and Engineering, Åbo Akademi University, Henrikinkatu 2, 20500 Turku, Finland.
Materials (Basel). 2021 Aug 26;14(17):4834. doi: 10.3390/ma14174834.
The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 °C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.
基于硅酸盐的生物活性玻璃S53P4在临床上以颗粒形式用于骨再生应用。然而，玻璃以支架形式的应用受到限制，因为玻璃在烧结过程中极易结晶。在此，通过仔细优化烧结参数，成功制造出了多孔无定形S53P4支架，其强度足以满足骨应用手术的要求（5兆帕）。烧结在实验室炉中于630℃下进行25至300分钟，即略低于结晶开始温度。用X射线衍射仪（XRD）验证了支架的相组成，并在体外测试了离子释放情况，并与颗粒在Tris缓冲液和模拟体液（SBF）连续流动中的情况进行了比较。无定形多孔S53P4支架为在更广泛的应用中使用该玻璃成分提供了可能性。
