神经生长因子：肺部疾病的潜在治疗靶点。

Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.

Department of Immunology, School of Basic Medical Sciences, Chengdu Medical College, Chengdu 610500, China.

Int J Mol Sci. 2021 Aug 24;22(17):9112. doi: 10.3390/ijms22179112.

The lungs play a very important role in the human respiratory system. However, many factors can destroy the structure of the lung, causing several lung diseases and, often, serious damage to people's health. Nerve growth factor (NGF) is a polypeptide which is widely expressed in lung tissues. Under different microenvironments, NGF participates in the occurrence and development of lung diseases by changing protein expression levels and mediating cell function. In this review, we summarize the functions of NGF as well as some potential underlying mechanisms in pulmonary fibrosis (PF), coronavirus disease 2019 (COVID-19), pulmonary hypertension (PH), asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Furthermore, we highlight that anti-NGF may be used in future therapeutic strategies.

肺在人体呼吸系统中起着非常重要的作用。然而，许多因素会破坏肺的结构，导致多种肺部疾病，并常常对人们的健康造成严重损害。神经生长因子（NGF）是一种广泛存在于肺组织中的多肽。在不同的微环境下，NGF 通过改变蛋白质表达水平和介导细胞功能，参与肺部疾病的发生和发展。本综述总结了 NGF 在肺纤维化（PF）、新型冠状病毒病 2019（COVID-19）、肺动脉高压（PH）、哮喘、慢性阻塞性肺疾病（COPD）和肺癌中的作用及其潜在的一些作用机制。此外，我们还强调了抗 NGF 可能用于未来的治疗策略。