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大口径中间导管取栓技术治疗卒中:单中心经验

Aspiration-Retriever Technique for Stroke with Large Bore Intermediate Catheter : A Single Center Experience.

作者信息

Nam Ji Won, Jung Na Young, Park Eun Suk, Kwon Soon Chan

机构信息

Department of Neurological Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.

出版信息

J Korean Neurosurg Soc. 2021 Sep;64(5):732-739. doi: 10.3340/jkns.2020.0308. Epub 2021 Sep 1.

Abstract

OBJECTIVE

Early successful reperfusion is associated with favorable outcomes in acute ischemic stroke (AIS). The purpose of this study was to achieve successful recanalization by a combined mechanical thrombectomy technique, the Aspiration-Retriever Technique for Stroke (ARTS), which is composed of a flexible large lumen distal access catheter and a retrievable stent as the first-line strategy of mechanical thrombectomy.

METHODS

We retrospectively reviewed 62 patients with AIS who underwent mechanical thrombectomy from 2018 to 2019 at our institute by a senior neurointerventionalist. Among them, patients who were treated using the ARTS technique with the soft torqueable catheter optimized for intracranial access (SOFIA®; MicroVention-Terumo, Tustin, CA, USA) as the first-line treatment were included. Patients who had tandem occlusions or underlying intracranial artery stenosis were excluded. The angiographic and clinical outcomes were evaluated. The angiographic outcome was analyzed by the rate of successful recanalization, defined as a Thrombolysis in Cerebral Infarction score of 2b or 3 at the end of all procedures and the rate of successfully achieving the first pass effect (FPE), defined as complete recanalization with a single pass of the device. The clinical outcomes included the National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale (mRS), and mortality.

RESULTS

A total of 27 patients (mean age, 59.3 years) fulfilled the inclusion criteria. The successful recanalization rate was 96% (n=26) while the FPE rate was 41% (n=11). The mean post-procedural NIHSS change was -3.0. Thirteen patients (48%) showed good clinical outcomes after thrombectomy with the ARTS technique (mRS at 90 days ≤2). Postoperative complications occurred in seven of 25 patients : hemorrhagic transformation in six patients (22%) and distal embolization in one patient (4%). Mortality was 15% (n=4).

CONCLUSION

Although the clinical outcomes using the ARTS technique with a flexible large lumen distal access catheter performed as the frontline thrombectomy in patients with AIS were not significantly superior than those of other studies, this study showed a high rate of successful endovascular recanalization which was comparable to that of other studies. Therefore, ARTS using the SOFIA® catheter can be considered as the first choice of treatment for AIS due to large vessel occlusion.

摘要

目的

急性缺血性卒中(AIS)早期成功再灌注与良好预后相关。本研究的目的是通过一种联合机械取栓技术,即卒中抽吸-取栓技术(ARTS)实现成功再通,该技术由一根可弯曲的大腔远端通路导管和一个可回收支架组成,作为机械取栓的一线策略。

方法

我们回顾性分析了2018年至2019年在我院由一位资深神经介入专家进行机械取栓的62例AIS患者。其中,包括那些将优化用于颅内通路的软可扭转导管(SOFIA®;美国加利福尼亚州图斯廷市MicroVention-Terumo公司)作为一线治疗采用ARTS技术治疗的患者。排除有串联闭塞或潜在颅内动脉狭窄的患者。评估血管造影和临床结果。血管造影结果通过成功再通率进行分析,成功再通定义为所有操作结束时脑梗死溶栓评分达到2b或3分,以及成功实现首次通过效应(FPE)的比率,首次通过效应定义为使用该装置单次通过实现完全再通。临床结果包括美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)和死亡率。

结果

共有27例患者(平均年龄59.3岁)符合纳入标准。成功再通率为96%(n = 26),而首次通过效应率为41%(n = 11)。术后NIHSS评分的平均变化为-3.0。13例患者(48%)采用ARTS技术取栓后显示出良好的临床结果(90天时mRS≤2)。25例患者中有7例发生术后并发症:6例患者(22%)出现出血转化,1例患者(4%)出现远端栓塞。死亡率为15%(n = 4)。

结论

尽管在AIS患者中使用可弯曲大腔远端通路导管的ARTS技术作为一线取栓的临床结果并不显著优于其他研究,但本研究显示出较高的血管内成功再通率,与其他研究相当。因此,使用SOFIA®导管的ARTS技术可被视为因大血管闭塞导致的AIS的首选治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88be/8435647/9f057e1a45be/jkns-2020-0308f1.jpg

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