使用微型计算机进行数据采集和分析的药代动力学及生理建模演示。

A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis.

作者信息

Kirkup L, Nichols D J, Sutherland J

机构信息

Physics Department, Paisley College of Technology, Scotland.

出版信息

Comput Appl Biosci. 1986 Dec;2(4):277-82. doi: 10.1093/bioinformatics/2.4.277.

DOI:10.1093/bioinformatics/2.4.277

PMID:3450372

Abstract

We describe a simple and inexpensive demonstration of mass transport and exchange using dye clearance from a hydrodynamic model. A microcomputer was used for data acquisition and storage, non-linear least squares curve fitting, compartmental analysis and parameter estimation. The system is useful for demonstrating the indicator-dilution technique for fluid volume measurement and compartmental analysis in pharmacokinetics.

摘要

我们描述了一种使用流体动力学模型中染料清除来进行质量传输和交换的简单且低成本的演示方法。使用微型计算机进行数据采集与存储、非线性最小二乘曲线拟合、房室分析和参数估计。该系统可用于演示药代动力学中流体体积测量和房室分析的指示剂稀释技术。