Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Department of Blood Transfusion, Affiliated Hospital of Nantong University, Nantong, 226001, China.
BMC Cardiovasc Disord. 2021 Sep 10;21(1):429. doi: 10.1186/s12872-021-02238-5.
Homocysteine (Hcy) is considered to be a risk factor for cardiovascular and cerebrovascular diseases. Few studies have evaluated the distribution of Hcy on a large-scale health examination. Accordingly, this study aimed to investigate the level and distribution of Hcy in the population with healthy physical examination and the correlation with other biomarkers, and analyzed for cardiovascular and other diseases.
Measurements of serum Hcy, TC, TG, LDL-c, HDL-c, ALT, ALP, γ-GT, TBIL, GLU, urea, Cr, UA, and related metabolic risk factors were selected for analysis from 8063 medical examination samples collected from February 2017 to April 2020. The relationship between Hcy and other biochemical indicators were evaluated with the multivariate regression model of age, gender, smoking, drinking, body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP).
Among 8063 cases, the age, BMI, SBP, and DBP of the high-Hcy group were higher than those of the low-Hcy group, the difference was statistically significant (P < 0.001), and the proportion of males, smoking, and drinking were higher than the low-Hcy group, the difference was statistically significant (P < 0.001); Hcy of the abnormal GLU group is higher than the normal GLU group (P = 0.002) and the Hcy of abnormal TG and HDL is higher than that of the normal blood lipid group (P < 0.001); Hcy of people with abnormal UA and Urea was higher than that of people with normal renal function (P < 0.001, P = 0.007). In multivariate analysis, lnHDL-C was negatively correlated with lnHcy (β = - 0.038, SE = 0.016, P = 0.019), lnCr was positively correlated with lnHcy (β = 0.055, SE = 0.016, P < 0.001), lnUA and lnHcy were positive correlated (β = 0.043, SE = 0.019, P = 0.022).
Hcy is closely related to HDL-c, Cr, and UA, which indicates that Hcy may affect the metabolism of HDL-c and UA, and can also be used as an auxiliary diagnostic index for kidney injury.
同型半胱氨酸（Hcy）被认为是心血管和脑血管疾病的危险因素。很少有研究在大规模体检中评估 Hcy 的分布。因此，本研究旨在探讨健康体检人群 Hcy 的水平和分布情况，以及与其他生物标志物的相关性，并分析其与心血管疾病等其他疾病的关系。
从 2017 年 2 月至 2020 年 4 月收集的 8063 例体检样本中选择血清 Hcy、TC、TG、LDL-c、HDL-c、ALT、ALP、γ-GT、TBIL、GLU、尿素、Cr、UA 及相关代谢危险因素进行分析。采用多元回归模型评估 Hcy 与其他生化指标的关系，模型中包含年龄、性别、吸烟、饮酒、体重指数（BMI）、收缩压（SBP）和舒张压（DBP）等因素。
在 8063 例患者中，高 Hcy 组的年龄、BMI、SBP 和 DBP 均高于低 Hcy 组，差异有统计学意义（P<0.001），男性、吸烟和饮酒的比例也高于低 Hcy 组，差异有统计学意义（P<0.001）；异常 GLU 组的 Hcy 高于正常 GLU 组（P=0.002），异常 TG 和 HDL 组的 Hcy 高于正常血脂组（P<0.001）；异常 UA 和 Urea 组的 Hcy 高于肾功能正常组（P<0.001，P=0.007）。多元分析中，lnHDL-C 与 lnHcy 呈负相关（β=-0.038，SE=0.016，P=0.019），lnCr 与 lnHcy 呈正相关（β=0.055，SE=0.016，P<0.001），lnUA 与 lnHcy 呈正相关（β=0.043，SE=0.019，P=0.022）。
Hcy 与 HDL-c、Cr 和 UA 密切相关，提示 Hcy 可能影响 HDL-c 和 UA 的代谢，也可作为肾损伤的辅助诊断指标。
