Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.
Institute of Medical Physics, Biophysics, Informatics and Telemedicine, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia.
Int J Environ Res Public Health. 2022 Oct 19;19(20):13521. doi: 10.3390/ijerph192013521.
Little research has been conducted into the effects of the combined manifestation of hyperuricemia and hyperhomocysteinemia on cardiometabolic risk factors and markers in young subjects.
1298 males and 1402 females, 14-to-20-year-olds, were classified into four groups: 1/normouricemic/normohomocysteinemic, 2/normouricemic/hyperhormohomocysteinemic, 3/hyperuricemic/normohomocysteinemic, and 4/hyperuricemic/hyperhomocysteinemic. Anthropometric measures, blood pressure, plasma glucose, insulin, lipids, markers of renal function, C-reactive protein, asymmetric dimethylarginine, and blood counts were determined.
Hyperuricemic males (but not females) had higher odds for hyperhomocysteinemia than normouricemic ones (OR: 1.8; 95% CI: 1.4-2.3; < 0.001). Homocysteine and uric acid levels correlated directly (males: r = 0.076, females: r = 0.120; < 0.01, both). Two-factor analysis of variance did not reveal a significant impact of hyperhomocysteinemia on any of the investigated cardiometabolic variables in females; in males, hyperuricemia and hyperhomocysteinemia showed a synergic effect on asymmetric dimethylarginine levels. Among four groups, subjects concurrently manifesting hyperuricemia and hyperhomocysteinemia did not presented the highest continuous metabolic syndrome score-a proxy measure of cardiometabolic risk; neither the multivariate regression model indicated a concurrent significant effect of uric acid and homocysteine on continuous metabolic syndrome score in either sex.
In young healthy subjects, hyperhomocysteinemia does not aggravate the negative health effects imposed by hyperuricemia.
鲜有研究关注高尿酸血症和高同型半胱氨酸血症合并表现对年轻人群中心血管代谢风险因素和标志物的影响。
1298 名男性和 1402 名女性，年龄在 14 至 20 岁之间，分为四组：1/血尿酸正常/同型半胱氨酸正常，2/血尿酸正常/高同型半胱氨酸血症，3/高尿酸血症/同型半胱氨酸正常，4/高尿酸血症/高同型半胱氨酸血症。测定了人体测量指标、血压、血糖、胰岛素、血脂、肾功能标志物、C 反应蛋白、不对称二甲基精氨酸和血细胞计数。
高尿酸血症男性（而非女性）发生高同型半胱氨酸血症的几率高于血尿酸正常者（比值比：1.8；95%可信区间：1.4-2.3；<0.001）。同型半胱氨酸和尿酸水平呈直接相关（男性：r = 0.076，女性：r = 0.120；<0.01，均）。两因素方差分析未显示高同型半胱氨酸血症对女性研究中任何心血管代谢变量有显著影响；在男性中，高尿酸血症和高同型半胱氨酸血症对不对称二甲基精氨酸水平有协同作用。在四组人群中，同时表现出高尿酸血症和高同型半胱氨酸血症的受试者并未表现出最高的连续代谢综合征评分（心血管代谢风险的替代指标）；多元回归模型也未表明在两性中尿酸和同型半胱氨酸同时对连续代谢综合征评分有显著影响。
在年轻健康人群中，高同型半胱氨酸血症不会加重高尿酸血症带来的负面健康影响。
