Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Sci Rep. 2021 Sep 10;11(1):18056. doi: 10.1038/s41598-021-97499-7.
Employing the magnets in therapy has a long history of treating diseases, and currently new applications such as drug delivery by magnetic nanoparticles are gaining more attention. This research tried to study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles carrying thrombolytic agents. In this research, FeO@SiO nanoparticles carrying streptokinase were applied. The efficiency of thrombolysis and micro-CT-scan images are utilized to study the effect of different magnetic fields (0.1, 0.2, 0.3 and 0.5 T) on thrombolysis. The results confirm that increasing the static magnetic field intensity accelerated the thrombolysis. Increasing the intensity of the magnetic field from 0.1 to 0.3 T leads to an increase in clot dissolution rate from 55 to 89%, respectively. Moreover, micro-CT-scan images revealed that magnetic nanoparticles carrying a thrombolytic agent penetrated deeper into the mesh-like structure of clot as the magnetic field intensities increased, which could lead to further dissolution of the clot.
利用磁场进行治疗的历史由来已久，可以治疗多种疾病，目前，新的应用，如利用磁性纳米颗粒输送药物，也引起了更多关注。本研究旨在探讨静磁场强度对载溶栓剂磁性纳米颗粒药物输送的影响。本研究中使用了负载链激酶的 FeO@SiO 纳米颗粒。通过溶栓效率和 micro-CT 扫描图像，研究了不同磁场（0.1、0.2、0.3 和 0.5 T）对溶栓的影响。结果证实，增加静磁场强度可以加速溶栓。磁场强度从 0.1 增加到 0.3 T，可使血栓溶解率分别从 55%增加到 89%。此外，micro-CT 扫描图像显示，随着磁场强度的增加，携带溶栓剂的磁性纳米颗粒更深入地穿透到血栓的网状结构中，这可能导致血栓进一步溶解。
