Department of Internal Medicine and Therapeutics. University of Health and Allied Sciences, School of Medicine. Ho Teaching Hospital, Ghana.
Department of Obstetrics and Gynecology, Ho Teaching Hospital. Ghana.
West Afr J Med. 2021 Aug 30;38(8):807-810.
Antiphospholipid syndrome is a systemic autoimmune disease characterized by thrombosis and/or pregnancy morbidity in the presence of persistently positive antiphospholipid antibodies. The finding of individuals who present a clinical picture highly suggestive of antiphospholipid syndrome, but who are persistently negative for "criteria" of antiphospholipid antibodies has led physicians to refer to this patient population as having "seronegative" Antiphospholipid syndrome. We present a case of a 35-years old patient with strong clinical suspicion of antiphospholipid syndrome, with a history of recurrent pregnancy loss and one episode of deep vein thrombosis, but serologically negative, who was admitted and successfully managed and discharged.
抗磷脂综合征是一种系统性自身免疫性疾病，其特征是存在持续阳性的抗磷脂抗体时发生血栓形成和/或妊娠并发症。某些个体表现出高度提示抗磷脂综合征的临床症状，但持续“标准”抗磷脂抗体阴性，这促使医生将这些患者群体称为“血清阴性”抗磷脂综合征。我们报告了一例 35 岁患者，强烈怀疑抗磷脂综合征，有复发性流产和一次深静脉血栓形成病史，但血清学阴性，该患者住院并成功得到管理和出院。
