Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
Clin Chim Acta. 2021 Dec;523:87-96. doi: 10.1016/j.cca.2021.09.004. Epub 2021 Sep 8.
Gestational diabetes mellitus (GDM) is the most common cause of hyperglycemia during pregnancy, and its prevalence has increased over the past decades. GDM is directly related to the recent obstetric outcomes and long-term maternal and child health, which can be greatly improved by early identification and diagnosis of GDM. However, the prediction of the disease has always been a difficult problem due to the lack of simple and practical serological markers. Despite the controversy, recent studies have identified that circulating inflammatory cells and platelets, routinely included in the obstetric blood tests, are related to the development of GDM and adverse pregnancy outcomes. In this review, we summarized the studies in this field based on the recent literature. The inflammatory cell components we included were the total number of white blood cells, neutrophils, lymphocytes, monocytes and platelets, which were routinely examined in the blood tests in pregnancy. The aim of this review is not only to enrich our understanding of the pathogenesis of GDM but also to provide evidence for the value of these novel and practical serological markers in early identification of GDM and the prevention and its adverse outcomes.
妊娠期糖尿病（GDM）是妊娠期间最常见的高血糖原因，其患病率在过去几十年中有所增加。GDM 与近期产科结局和母婴长期健康密切相关，通过早期识别和诊断 GDM 可以显著改善这些结局。然而，由于缺乏简单实用的血清标志物，疾病的预测一直是一个难题。尽管存在争议，但最近的研究表明，循环炎症细胞和血小板是常规产科血液检查的一部分，与 GDM 的发生和不良妊娠结局有关。在本综述中，我们根据最近的文献综述了该领域的研究。我们纳入的炎症细胞成分包括白细胞总数、中性粒细胞、淋巴细胞、单核细胞和血小板，这些都是妊娠期间血液检查中常规检查的项目。本综述的目的不仅在于丰富我们对 GDM 发病机制的认识，还在于为这些新型实用血清标志物在 GDM 的早期识别、预防及其不良结局方面的价值提供证据。
