Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Sci Rep. 2023 Nov 28;13(1):20963. doi: 10.1038/s41598-023-48371-3.
Gestational diabetes mellitus (GDM) is a major complication of pregnancy. GDM is associated with a higher risk of adverse pregnancy outcomes (APO). The purpose of this study was to assess the association between third-trimester platelet to lymphocyte ratio (PLR) and high-sensitivity C-reactive protein (hsCRP) concentration and the risk of APO in GDM pregnant women. This study selected 406 non-elderly gestational diabetes patients diagnosed in the Renmin Hospital of Wuhan University from May 2021 to February 2023 as the research objects. According to the presence or absence of APO, they were divided into an APO group (n = 171) and a non-APO group (n = 235). Logistic regression model to evaluate the correlation between PLR and hsCRP and APO in women with GDM; Restricted cubic spline analyses was used to explore nonlinear correlations between PLR or hsCRP and the risk of APO; ROC curve analysis of the diagnostic performance of PLR and hsCRP for APO in women with GDM. APO occurred in 171 of the 406 included participants. Compared with the non-APO group, patients in the APO group had higher PLR and hsCRP levels. The incidence of APO was positively associated with PLR and the hsCRP level in each logistic regression model (P < 0.05). After adjusting for all the risk factors included in this study, restricted cubic spline analyses found that the PLR and the hsCRP level were positively associated with the risk of APO. The levels of PLR and hsCRP in the third trimester are related to the occurrence of APO in women with GDM, and high levels of PLR and hsCRP may indicate the occurrence of APO.
妊娠期糖尿病（GDM）是妊娠的主要并发症。GDM 与不良妊娠结局（APO）的风险增加有关。本研究旨在评估妊娠晚期血小板与淋巴细胞比值（PLR）和高敏 C 反应蛋白（hsCRP）浓度与 GDM 孕妇 APO 风险之间的关系。本研究选取 2021 年 5 月至 2023 年 2 月在武汉大学人民医院诊断的 406 例非老年妊娠期糖尿病患者为研究对象。根据是否存在 APO，将其分为 APO 组（n=171）和非 APO 组（n=235）。采用 Logistic 回归模型评估 PLR 和 hsCRP 与 GDM 妇女 APO 的相关性；采用受限立方样条分析探讨 PLR 或 hsCRP 与 APO 风险之间的非线性关系；ROC 曲线分析 PLR 和 hsCRP 对 GDM 妇女 APO 的诊断性能。406 名纳入参与者中有 171 名发生 APO。与非 APO 组相比，APO 组患者的 PLR 和 hsCRP 水平更高。在每个 logistic 回归模型中，APO 的发生率与 PLR 和 hsCRP 水平呈正相关（P<0.05）。在校正本研究中包含的所有危险因素后，受限立方样条分析发现 PLR 和 hsCRP 水平与 APO 风险呈正相关。妊娠晚期 PLR 和 hsCRP 水平与 GDM 妇女 APO 的发生有关，高水平的 PLR 和 hsCRP 可能预示着 APO 的发生。
