Department of Pathogen Biology, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
Virus Genes. 2021 Dec;57(6):475-488. doi: 10.1007/s11262-021-01869-2. Epub 2021 Sep 11.
Throughout the viral life cycle, interplays between cellular host factors and virus determine the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a great threat to human life and health. Extensive studies identified a number of host proviral and antiviral factors for SARS-CoV-2. In this review, we summarize the current understanding of the interplay between SARS-CoV-2 and cellular factors during virus entry and replication. Our review will highlight the future direction of study on the infection and pathogenesis of SARS-CoV-2, as well as novel therapeutic strategies and effective antiviral targets for COVID-19.
在整个病毒生命周期中，细胞宿主因素与病毒之间的相互作用决定了病毒的感染能力。由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）大流行对人类生命和健康构成了巨大威胁。广泛的研究确定了许多宿主促进病毒复制和抗病毒的因素。在这篇综述中，我们总结了目前对 SARS-CoV-2 进入细胞和复制过程中与细胞因子相互作用的理解。我们的综述将突出 SARS-CoV-2 感染和发病机制的未来研究方向，以及 COVID-19 的新型治疗策略和有效的抗病毒靶点。
