Biophysics Department, Faculty of Science, Cairo University, Giza 12511, Egypt.
Physics Department, Faculty of Science, Alexandria University, Alexandria 21519, Egypt.
Molecules. 2021 Oct 26;26(21):6455. doi: 10.3390/molecules26216455.
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now, it represents a significant global health and economic burden. The newly emerged coronavirus disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the primary reason for the COVID-19 global pandemic. According to recent global figures, COVID-19 has caused approximately 243.3 million illnesses and 4.9 million deaths. Several human cell receptors are involved in the virus identification of the host cells and entering them. Hence, understanding how the virus binds to host-cell receptors is crucial for developing antiviral treatments and vaccines. The current work aimed to determine the multiple host-cell receptors that bind with SARS-CoV-2 and other human coronaviruses for the purpose of cell entry. Extensive research is needed using neutralizing antibodies, natural chemicals, and therapeutic peptides to target those host-cell receptors in extremely susceptible individuals. More research is needed to map SARS-CoV-2 cell entry pathways in order to identify potential viral inhibitors.
一种新型人类冠状病毒在 2019 年末引起了相当大的关注。如今，它给全球健康和经济带来了巨大的负担。由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的新型冠状病毒疾病是 COVID-19 全球大流行的主要原因。根据最近的全球数据，COVID-19 已导致约 2.433 亿例疾病和 490 万人死亡。几种人类细胞受体参与病毒对宿主细胞的识别和进入。因此，了解病毒如何与宿主细胞受体结合对于开发抗病毒治疗方法和疫苗至关重要。目前的工作旨在确定与 SARS-CoV-2 和其他人类冠状病毒结合以进入细胞的多种宿主细胞受体。需要使用中和抗体、天然化学物质和治疗性肽进行广泛研究，以针对那些极易受感染的个体的宿主细胞受体。需要进一步研究 SARS-CoV-2 细胞进入途径，以确定潜在的病毒抑制剂。
