Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India.
Can J Neurol Sci. 2022 Nov;49(6):809-812. doi: 10.1017/cjn.2021.216. Epub 2021 Sep 13.
Applause sign (AS) is a clinical phenomenon observed in several neurological disorders including progressive supranuclear palsy (PSP). We investigated the factors associated with AS in patients with PSP. PSP patients with AS showed greater motor impairment compared to those with negative AS. Global cognition including attention and memory were affected more in patients with positive AS. We also observed that gait variability, a known marker for unstable gait is pronounced in those who presented with positive AS. Hence, the clinician might expect a more severe disease and an unstable gait in a PSP patient presenting with AS.
鼓掌征（AS）是几种神经退行性疾病中观察到的一种临床现象，包括进行性核上性麻痹（PSP）。我们研究了与 PSP 患者 AS 相关的因素。与无 AS 的患者相比，有 AS 的 PSP 患者运动障碍更严重。注意力和记忆力等整体认知功能在有 AS 的患者中受影响更大。我们还观察到，步态变异性，一种已知的不稳定步态标志物，在有 AS 的患者中更为明显。因此，在有 AS 的 PSP 患者中，临床医生可能会预期更严重的疾病和不稳定的步态。
