Peng Jui-Wen, Nfor Oswald Ndi, Ho Chien-Chang, Hsu Shu-Yi, Lung Chia-Chi, Tantoh Disline Manli, Chou Ming-Chih, Liaw Yung-Po
Institute of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan.
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, 40201, Taiwan.
Pharmgenomics Pers Med. 2021 Aug 31;14:1087-1092. doi: 10.2147/PGPM.S310675. eCollection 2021.
Ischemic stroke accounts for approximately 85% of all strokes. Risk factors include atrial fibrillation, metabolic disorders, and genetic and lifestyle factors. There is limited evidence to support the association between atrial fibrillation and the risk of ischemic stroke based on genetic variants. We assessed the relationship between ischemic stroke and atrial fibrillation among participants in Taiwan Biobank (TWB) based on the rs2860905 variant of the cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) gene.
Using logistic regression analysis, we estimated the odds ratios (OR) and 95% confidence intervals (CI) for ischemic stroke among 17,726 biobank adults recruited from 2008 through 2015.
Of the eligible participants (n = 17,726), 906 were identified with ischemic stroke. Atrial fibrillation was positively associated with ischemic stroke (OR=3.70; 95% CI, 2.21-6.20), whereas the rs2860905 variant was not. The OR for ischemic stroke among those with GA/AA genotype was 1.00 (95% CI, 0.82-1.22) compared to those with the GG genotype. Based on the genotype-stratified analysis, the OR for ischemic stroke was 4.68 (95% CI, 2.70-8.09) among individuals with GG genotype who had atrial fibrillation compared to those who did not.
These results demonstrate that the GG genotype of the CYP2C9 rs2860905 variant appears to enhance the risk of ischemic stroke among adults in Taiwan. It could be essential to factor this genotype-specific contributor to ischemic stroke into clinical and experimental investigations of the disease in Taiwan.
缺血性中风约占所有中风的85%。风险因素包括心房颤动、代谢紊乱以及遗传和生活方式因素。基于基因变异，支持心房颤动与缺血性中风风险之间关联的证据有限。我们基于细胞色素P450家族2亚家族C成员9（CYP2C9）基因的rs2860905变异，评估了台湾生物银行（TWB）参与者中缺血性中风与心房颤动之间的关系。
我们使用逻辑回归分析，估计了2008年至2015年招募的17726名生物银行成年参与者发生缺血性中风的比值比（OR）和95%置信区间（CI）。
在符合条件的参与者（n = 17726）中，906人被确诊为缺血性中风。心房颤动与缺血性中风呈正相关（OR = 3.70；95% CI，2.21 - 6.20），而rs2860905变异则不然。与GG基因型者相比，GA/AA基因型者发生缺血性中风的OR为1.00（95% CI，0.82 - 1.22）。基于基因型分层分析，与未患心房颤动的GG基因型个体相比，患心房颤动的GG基因型个体发生缺血性中风的OR为4.68（95% CI，2.70 - 8.09）。
这些结果表明，CYP2C9 rs2860905变异的GG基因型似乎会增加台湾成年人患缺血性中风的风险。在台湾对该疾病进行临床和实验研究时，将这种特定基因型导致缺血性中风的因素考虑在内可能至关重要。
