Ekhart Corine, van Hunsel Florence, van Harten Peter, van Baarsen Jeanette, Yingying Tan, Bast Bert
Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, Netherlands.
Research Department, Psychiatric Centre GGz Centraal, Innova, Amersfoort, Netherlands.
Front Psychiatry. 2021 Aug 25;12:692568. doi: 10.3389/fpsyt.2021.692568. eCollection 2021.
Stuttering is a well-known condition that affects mainly children. Often, they recover as they get older. However, a drug-induced form of stuttering may occur at any age. The aim of the present study was to detect drugs that have been associated with stuttering and discuss the mechanisms involved. A descriptive study based on reports submitted to the global pharmacovigilance database VigiBase of the WHO was conducted. A total of 3,385 reports of dysphemia were retrieved from VigiBase. These reports were contributed by 51 countries. Antiepileptics, antidepressants, immunosuppressants, antipsychotics, and centrally acting sympathomimetics were among the most frequently implicated drugs. A wide variety of drugs has been linked to the occurrence or recurrence of stuttering. Several mechanisms, such as increased dopamine levels, reduction of GABA, anticholinergic properties of drugs, or changes in serotonin levels, have been associated with the development of drug-induced stuttering. Paradoxically, agents known to reduce stuttering in some people may induce it in others.
口吃是一种主要影响儿童的常见病症。通常，随着年龄增长他们会自愈。然而，药物诱发的口吃可能在任何年龄出现。本研究的目的是检测与口吃相关的药物，并探讨其中涉及的机制。开展了一项基于提交给世界卫生组织全球药物警戒数据库VigiBase的报告的描述性研究。从VigiBase中检索到了总共3385份言语障碍报告。这些报告由51个国家提供。抗癫痫药、抗抑郁药、免疫抑制剂、抗精神病药和中枢作用拟交感神经药是最常涉及的药物。各种各样的药物都与口吃的发生或复发有关。几种机制，如多巴胺水平升高、γ-氨基丁酸减少、药物的抗胆碱能特性或血清素水平变化，都与药物诱发口吃的发展有关。矛盾的是，已知在某些人身上能减轻口吃的药物可能会在另一些人身上诱发口吃。
