Joshkon Ahmad, Heim Xavier, Dubrou Cléa, Bachelier Richard, Traboulsi Wael, Stalin Jimmy, Fayyad-Kazan Hussein, Badran Bassam, Foucault-Bertaud Alexandrine, Leroyer Aurelie S, Bardin Nathalie, Blot-Chabaud Marcel
Hematology Department, Center for CardioVascular and Nutrition Research C2VN, Faculty of Pharmacy, Timone Campus, Aix-Marseille University, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche Pour L'agriculture, L'alimentation et L'environnement (INRAE), 13005 Marseille, France.
Laboratory of Cancer Biology and Molecular Immunology, Faculty of Science, Lebanese University, Hadath 1104, Lebanon.
Biomedicines. 2020 Dec 19;8(12):633. doi: 10.3390/biomedicines8120633.
The fundamental role of cell adhesion molecules in mediating various biological processes as angiogenesis has been well-documented. CD146, an adhesion molecule of the immunoglobulin superfamily, and its soluble form, constitute major players in both physiological and pathological angiogenesis. A growing body of evidence shows soluble CD146 to be significantly elevated in the serum or interstitial fluid of patients with pathologies related to deregulated angiogenesis, as autoimmune diseases, obstetric and ocular pathologies, and cancers. To block the undesirable effects of this molecule, therapeutic antibodies have been developed. Herein, we review the multifaceted functions of CD146 in physiological and pathological angiogenesis and summarize the interest of using monoclonal antibodies for therapeutic purposes.
细胞粘附分子在介导诸如血管生成等各种生物学过程中的基本作用已得到充分证明。CD146是免疫球蛋白超家族的一种粘附分子，其可溶性形式在生理和病理血管生成中均起主要作用。越来越多的证据表明，在与血管生成失调相关的疾病患者的血清或组织液中，可溶性CD146会显著升高，这些疾病包括自身免疫性疾病、产科和眼科疾病以及癌症。为了阻断该分子的不良影响，已开发出治疗性抗体。在此，我们综述了CD146在生理和病理血管生成中的多方面功能，并总结了使用单克隆抗体进行治疗的意义。
