Farhat Wassim, Pariente Aaron, Mijahed Rami
Department of Neurology and Stroke Unit, Fondation Hôpital Saint Joseph, Paris, France.
Department of Emergency, Fondation Hôpital Saint Joseph, Paris, France.
Cerebrovasc Dis. 2022;51(1):114-117. doi: 10.1159/000518524. Epub 2021 Sep 7.
Nitrous oxide, colloquially known as "whippets," is a commonly abused inhalant by adolescents and young adults. There are limited data describing the adverse effects of this abuse. We present a 16-year-old girl with no medical history who presented to the emergency department for confusion, hallucinations, weakness, and headaches. Imaging revealed extensive cerebral thrombosis. She had no prior history of venous or arterial thrombosis. Hypercoagulability workup demonstrated an elevated homocysteine level. She was treated with effective anticoagulation and vitamin B12 folate supplementation. To our knowledge, there are a very few cases in the medical literature of cerebral venous thrombosis following the use of nitrous oxide. The pathophysiology of the disorder appears to be linked to the metabolism of vitamin B12 inducing hyperhomocysteinemia and a procoagulant state.
一氧化二氮，俗称“ippets”，是青少年和年轻人中常见的滥用吸入剂。描述这种滥用的不良影响的数据有限。我们报告一名16岁无病史的女孩，因意识模糊、幻觉、虚弱和头痛就诊于急诊科。影像学检查显示广泛的脑血栓形成。她既往无静脉或动脉血栓形成病史。高凝状态检查显示同型半胱氨酸水平升高。她接受了有效的抗凝治疗及维生素B12和叶酸补充治疗。据我们所知，医学文献中因使用一氧化二氮后发生脑静脉血栓形成的病例极少。该病症的病理生理学似乎与维生素B12代谢导致高同型半胱氨酸血症和促凝状态有关。
