Nguyen Nancy, Cao Jessica, Carlson Deborah, Kong Lynn, Diaz Graal
Medicine, Community Memorial Health Systems, Ventura, USA.
Medicine, Western University of Health Sciences, Pomona, USA.
Cureus. 2024 Sep 13;16(9):e69347. doi: 10.7759/cureus.69347. eCollection 2024 Sep.
Nitrous oxide (N2O) has a lengthy history of use as an anesthetic and has recently found popularity as a recreational euphoric hallucinogen. The odorless, colorless, non-flammable gas interferes with Vitamin B12 resulting in a cascade of effects, including hyperhomocysteinemia. It has long been proposed that hyperhomocysteinemia adversely affects the cardiovascular system, producing atherogenic and prothrombotic diseases. In this case vignette, we describe a case in which a healthy patient presented with venous thromboembolism (VTE) that we suspect could have been precipitated by daily and significant recreational use of N2O. Anticoagulation therapy was given, and there was a significant improvement in the pulmonary emboli. As recreational use of N2O increases, it is essential to recognize that hyperhomocysteinemia may also produce a thrombotic state.
一氧化二氮（N₂O）作为麻醉剂有着悠久的使用历史，最近它作为一种能带来欣快感的致幻剂在娱乐用途中受到欢迎。这种无色无味、不可燃的气体干扰维生素B₁₂，导致一系列影响，包括高同型半胱氨酸血症。长期以来，人们一直认为高同型半胱氨酸血症会对心血管系统产生不利影响，引发动脉粥样硬化和血栓形成性疾病。在本病例报告中，我们描述了一名健康患者出现静脉血栓栓塞（VTE）的病例，我们怀疑这可能是由于每日大量娱乐性使用N₂O所致。给予了抗凝治疗，肺栓塞有了显著改善。随着N₂O娱乐性使用的增加，认识到高同型半胱氨酸血症也可能导致血栓形成状态至关重要。
