Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA.
Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health, New York, NY 10016, USA.
Sci Immunol. 2021 Sep 10;6(63):eabg3551. doi: 10.1126/sciimmunol.abg3551. Epub 2021 Sep 3.
Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance of lymph node metastasis for distant spread, however, has been questioned by large-scale lymph node dissection trials and the likely prevalence of direct hematogenous metastasis. Still, an emerging appreciation for the immunological role of the tumor-draining lymph node has renewed interest in its basic biology, role in metastatic progression, antitumor immunity, and patient outcomes. In this review, we discuss our current understanding of the early mechanisms through which tumors engage lymphatic transport and condition tumor-draining lymph nodes, the significance of these changes for both metastasis and immunity, and potential implications of the tumor-draining lymph node for immunotherapy.
实体瘤在周围非淋巴组织中早期与淋巴系统的相互作用是癌症的一个临床特征，通常预示着预后不良。然而，淋巴结转移对远处扩散的意义受到了大规模淋巴结清扫试验和直接血行转移的可能性的质疑。尽管如此，人们对肿瘤引流淋巴结的免疫作用的认识不断提高，重新激发了人们对其基础生物学、在转移进展、抗肿瘤免疫和患者预后中的作用的兴趣。在这篇综述中，我们讨论了我们目前对肿瘤参与淋巴运输和调节肿瘤引流淋巴结的早期机制的理解，这些变化对转移和免疫的重要性，以及肿瘤引流淋巴结对免疫治疗的潜在影响。
