Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY 10016.
Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY 10016;
J Immunol. 2021 Jan 15;206(2):264-272. doi: 10.4049/jimmunol.2001060.
Lymphatic vessels provide an anatomical framework for immune surveillance and adaptive immune responses. Although appreciated as the route for Ag and dendritic cell transport, peripheral lymphatic vessels are often not considered active players in immune surveillance. Lymphatic vessels, however, integrate contextual cues that directly regulate transport, including changes in intrinsic pumping and capillary remodeling, and express a dynamic repertoire of inflammatory chemokines and adhesion molecules that facilitates leukocyte egress out of inflamed tissue. These mechanisms together contribute to the course of peripheral tissue immunity. In this review, we focus on context-dependent mechanisms that regulate fluid and cellular transport out of peripheral nonlymphoid tissues to provide a framework for understanding the effects of afferent lymphatic transport on immune surveillance, peripheral tissue inflammation, and adaptive immunity.
淋巴管为免疫监视和适应性免疫反应提供了一个解剖学框架。尽管淋巴管被认为是抗原和树突状细胞运输的途径，但外周淋巴管通常不被认为是免疫监视的活跃参与者。然而，淋巴管整合了直接调节运输的上下文线索，包括内在泵送和毛细血管重塑的变化，并表达了一系列动态的炎症趋化因子和粘附分子，促进白细胞从炎症组织中逸出。这些机制共同促成了外周组织免疫的过程。在这篇综述中，我们重点关注调节外周非淋巴组织中液体和细胞运输的依赖于上下文的机制，为理解传入淋巴管运输对免疫监视、外周组织炎症和适应性免疫的影响提供了一个框架。
