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心力衰竭和射血分数降低患者的非心脏病学与心脏病学治疗与更低的指南为基础的治疗使用率和更高的死亡率相关:来自瑞典心力衰竭注册研究的观察结果。

Non-cardiology vs. cardiology care of patients with heart failure and reduced ejection fraction is associated with lower use of guideline-based care and higher mortality: Observations from The Swedish Heart Failure Registry.

机构信息

Cardiology Department, Laiko General Hospital, Athens, Greece.

Cardiology Unit, Department of Internal Medicine, University of Genoa, Italy; Ospedale Policlinico San Martino IRCCS, Genoa, Italy.

出版信息

Int J Cardiol. 2021 Nov 15;343:63-72. doi: 10.1016/j.ijcard.2021.09.013. Epub 2021 Sep 10.

DOI:10.1016/j.ijcard.2021.09.013
PMID:34517016
Abstract

BACKGROUND

Patients with heart failure (HF) are often cared for by non-cardiologists. The implications are unknown.

METHODS

In a nationwide HF cohort with reduced ejection fraction (HFrEF), we compared demographics, clinical characteristics, guideline-based therapy use and outcomes in non-cardiology vs. cardiology in-patient and out-patient care.

RESULTS

Between 2000 and 2016, 36,076 patients with HFrEF were enrolled in the Swedish HF registry (19,337 [54%] in-patients overall), with 44% of in-patients and 45% of out-patients managed in non-cardiology settings. Predictors of treatment in non-cardiology were age > 75 years (adjusted odds ratio for non-cardiology 1.20; 95% confidence interval 1.14-1.27), lower education level (0.71; 0.66-0.76 for university vs. compulsory), valve disease (1.24; 1.18-1.31) and systolic blood pressure (SBP) >120 mmHg (1.05; 1.00-1.10). Non-cardiology care was significantly associated with lower use of beta-blockers (0.80; 0.74-0.86) and devices (intracardiac defibrillator [ICD] and/or cardiac resynchronization therapy [CRT]: 0.63; 0.56-0.71), and less frequent specialist follow-up (0.61; 0.57-0.65). Over 1-year follow-up the risk of all-cause mortality (adjusted hazard ratio 1.09; 1.03-1.15) was higher but the risk of first HF (re-) hospitalization was lower (0.93; 0.89-0.97) in non-cardiology vs. cardiology care.

CONCLUSIONS

In HFrEF, non-cardiology care was independently associated with older ageand lower education. After covariate adjustment, non-cardiology care was associated with lower use of beta-blockers and devices, higher mortality, and lower risk of HF hospitalization. Access to cardiology care may not be equitable and this may have implications for use of guideline-based care and outcomes.

摘要

背景

心力衰竭(HF)患者通常由非心脏病专家护理。其影响尚不清楚。

方法

在一个射血分数降低的心力衰竭(HFrEF)的全国性 HF 队列中,我们比较了非心脏病学与心脏病学的住院和门诊护理中患者的人口统计学、临床特征、基于指南的治疗方法使用情况和结局。

结果

在 2000 年至 2016 年间,瑞典 HF 注册中心共登记了 36076 例 HFrEF 患者(总体上有 19337 例[54%]住院患者),其中 44%的住院患者和 45%的门诊患者在非心脏病学环境中接受治疗。非心脏病学治疗的预测因素为年龄>75 岁(非心脏病学的调整比值比为 1.20;95%置信区间 1.14-1.27)、教育水平较低(大学 vs. 义务教育,0.71;0.66-0.76)、瓣膜疾病(1.24;1.18-1.31)和收缩压(SBP)>120mmHg(1.05;1.00-1.10)。非心脏病学治疗与β受体阻滞剂(0.80;0.74-0.86)和器械(心脏内除颤器[ICD]和/或心脏再同步治疗[CRT]:0.63;0.56-0.71)的使用率较低以及专科随访频率较低(0.61;0.57-0.65)显著相关。在 1 年的随访中,全因死亡率的风险(调整后的危险比 1.09;1.03-1.15)较高,但非心脏病学治疗的首次心力衰竭(再)住院风险较低(0.93;0.89-0.97)。

结论

在 HFrEF 中,非心脏病学治疗与年龄较大和教育程度较低独立相关。在调整协变量后,非心脏病学治疗与β受体阻滞剂和器械的使用率较低、死亡率较高以及心力衰竭住院风险较低相关。获得心脏病学治疗的机会可能并不公平,这可能对基于指南的治疗方法的使用和结局产生影响。

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