Rubio-Tomás Teresa, Rueda-Robles Ascensión, Plaza-Díaz Julio, Álvarez-Mercado Ana I
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; School of Medicine, University of Crete, Herakleion, Crete, Greece.
Institute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Armilla, Granada, Spain.
J Nutr Biochem. 2022 Jan;99:108861. doi: 10.1016/j.jnutbio.2021.108861. Epub 2021 Sep 11.
Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of adipose tissue, liver, pancreas, and the nervous system. Inflammation is related to cellular senescence, distinguished by irreversible cell cycle arrest. Senescent cells secrete the senescence-associated secretory phenotype (SASP) which contains pro-inflammatory factors. Targeting processes in senescence might have a salutary approach to obesity. The present review highlights the impact of an unhealthy diet on tissues affected by obesity, and the mechanisms that promote the consequent inflammation and senescence.
充足的营养对免疫稳态至关重要。然而，由于西方饮食的采用和久坐不动的生活方式，全球肥胖症的发病率正在上升。肥胖与慢性炎症相关，慢性炎症会改变脂肪组织、肝脏、胰腺和神经系统的功能。炎症与细胞衰老有关，其特征是不可逆的细胞周期停滞。衰老细胞分泌包含促炎因子的衰老相关分泌表型（SASP）。针对衰老过程可能是治疗肥胖症的有益方法。本综述强调了不健康饮食对受肥胖影响的组织的影响，以及促进随之而来的炎症和衰老的机制。
