Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Int J Mol Sci. 2021 Feb 12;22(4):1839. doi: 10.3390/ijms22041839.
Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper-metabolic profile necessary to support the increased immune activation of AT-derived B cells as compared to blood-derived B cells. This hyper-metabolic profile is needed for the secretion of the pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) that fuel local and systemic inflammation.
衰老细胞在肥胖个体的脂肪组织（AT）中积累，并分泌多种构成衰老相关分泌表型（SASP）的因子。本文旨在比较肥胖个体的 AT 和外周血中的 B 细胞，鉴定具有 SASP 表型的 B 细胞。我们的结果显示，与血液 B 细胞相比，AT 中的 SASP 标志物表达增加，这种表型与高代谢特征相关，这是支持 AT 来源的 B 细胞比血液来源的 B 细胞的免疫激活增加所必需的。这种高代谢特征是分泌促炎介质（细胞因子、趋化因子、micro-RNAs）所必需的，这些介质会引发局部和全身炎症。
