人甲状腺中27S和19S甲状腺球蛋白及其激素含量的分析。

Analysis of thyroglobulins 27S and 19S and their hormonal content in human thyroid glands.

作者信息

Carvalho D P, Rosenthal D, Breitenbach M M

机构信息

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.

出版信息

Braz J Med Biol Res. 1987;20(3-4):415-8.

PMID:3451789

Abstract

Thyroglobulins (Tg) 27S and 19S and their hormonal content were determined in normal (N = 6), paranodular (N = 4) and hypofunctioning nodular (N = 8) human thyroid tissues. The proportion of Tg 27S and the hormonal content of Tg 19S were significantly decreased in cold nodules. In normal tissues, the molar ratio of T4 in Tg 27S (2.8) was almost twice that found in Tg 19S (1.7), while for T3 the molar ratio in Tg 27S (0.06) was lower than in Tg 19S (0.09). These results indicate that Tg 27S is predominantly formed from well iodinated T4-containing Tg 19S molecules.

摘要

在正常（N = 6）、结节旁（N = 4）和功能减退结节性（N = 8）人甲状腺组织中测定了甲状腺球蛋白（Tg）27S和19S及其激素含量。冷结节中Tg 27S的比例和Tg 19S的激素含量显著降低。在正常组织中，Tg 27S中T4的摩尔比（2.8）几乎是Tg 19S中（1.7）的两倍，而对于T3，Tg 27S中的摩尔比（0.06）低于Tg 19S中的（0.09）。这些结果表明，Tg 27S主要由含碘良好的含T4的Tg 19S分子形成。