癌前病变和癌症患者胃液中的癌胚抗原水平

CEA levels in gastric juice in precancerous conditions and cancer.

作者信息

Amadori D, Ravaioli A, Biserni R, Bonaguri C, Erbacci P, Pallotti G, Ronchi A, Saragoni A, Falcini F

机构信息

Oncology Department, G.B. Morgagni -L. Pierantoni Hospital, Vecchiazzano, Forlì, Italy.

出版信息

Int J Biol Markers. 1987 May-Aug;2(2):101-4. doi: 10.1177/172460088700200208.

DOI:10.1177/172460088700200208

PMID:3451930

Abstract

First described in 1965 as a specific antigen for cancer of the colon, CEA is now considered to be an antigen associated with many types of malignant neoplasia, although the CEA-Test's role in clinical routine has yet to be clearly defined. In the present study CEA levels in gastric juice were measured in subjects with gastric carcinoma (n = 25) and with benign gastric lesions (n = 171). CEA was significantly (p less than 0.05) higher in patients with gastric carcinoma (GC) than in subjects with benign gastric lesions, other than chronic atrophic gastritis (CAG) associated with intestinal metaplasia (IM). In this latter condition CEA levels were similar to those in patients with GC. These results suggest that the assay of CEA in gastric juice could be included in the diagnostic program for gastric cancer and its precursors with the aim of assessing its utility as risk indicator in the management of precancerous conditions and lesion.

摘要

癌胚抗原（CEA）于1965年首次被描述为结肠癌的一种特异性抗原，尽管CEA检测在临床常规中的作用尚未明确界定，但现在它被认为是一种与多种恶性肿瘤相关的抗原。在本研究中，对患有胃癌的受试者（n = 25）和患有良性胃部病变的受试者（n = 171）的胃液中CEA水平进行了测量。除了与肠化生（IM）相关的慢性萎缩性胃炎（CAG）外，胃癌（GC）患者的CEA水平显著高于（p < 0.05）患有良性胃部病变的受试者。在后一种情况下，CEA水平与GC患者的水平相似。这些结果表明，胃液中CEA的检测可纳入胃癌及其前驱病变的诊断程序中，目的是评估其作为癌前病变管理中风险指标的效用。