Saito N, Kimura M, Kuchiba A, Itokawa Y
Department of Geriatrics, Kochi Medical University, Japan.
J Nutr Sci Vitaminol (Tokyo). 1987 Dec;33(6):421-30. doi: 10.3177/jnsv.33.421.
In 46 diabetic outpatients consisting of 20 males and 26 females not given thiamine treatment, the blood thiamine level was 46.9 +/- 28.5 ng/ml (mean +/- SD) and only 23.9% of all cases had a value of more than the normal lower limit (50 ng/ml). Erythrocyte transketolase activity was 443.8 +/- 107.7 micrograms/ml/h and only 20.9% had a value of ore than the normal lower limit (50 micrograms/ml/h), and the erythrocyte TPP effect was 16.6 +/- 13.2%. Moreover, there was a significant positive correlation (r = 0.97) between the blood thiamine level and erythrocyte transketolase activity, and a significant inverse correlation (r = -0.525, r = -0.576) between blood thiamine level and/or erythrocyte transketolase activity and the erythrocyte TPP effect. In 24 diabetic outpatients consisting of 14 males and 10 females given thiamine treatment, the blood thiamine level was 96.5 +/- 44.5 ng/ml/h excluding one case (621.7 ng/ml), and it was higher than the normal lower limit in 83% of all cases. Erythrocyte transketolase activity was 513.9 +/- 133.4 micrograms/ml/h and it was higher than the normal lower limit in 58.3%. Erythrocyte TPP effect was 5.84 +/- 8.39%. There was also a significant positive correlation (r = 0.663) between blood thiamine level and erythrocyte transketolase activity, and a significant inverse correlation (r = 0.0668, r = 0.834) between blood thiamine level and/or erythrocyte transketolase activity and erythrocyte TPP effect. Blood thiamine level and erythrocyte transketolase activity were significantly higher in diabetic outpatients given thiamine treatment than in diabetic outpatients not given thiamine treatment, while the erythrocyte TPP effect was significantly lower in diabetic outpatients given thiamine treatment than in diabetic outpatients not given thiamine treatment. There was no direct relationship between the lowered response of patellar tendon reflex and the biochemical status of thiamine. From the above findings it was concluded that diabetic outpatients tend to have a low blood thiamine level, with low erythrocyte transketolase activity and high erythrocyte TPP effect, and showed marginal thiamine deficiency.
在46例未接受硫胺素治疗的糖尿病门诊患者中，包括20名男性和26名女性，血液硫胺素水平为46.9±28.5 ng/ml（均值±标准差），所有病例中只有23.9%的值高于正常下限（50 ng/ml）。红细胞转酮醇酶活性为443.8±107.7微克/毫升/小时，只有20.9%的值高于正常下限（50微克/毫升/小时），红细胞TPP效应为16.6±13.2%。此外，血液硫胺素水平与红细胞转酮醇酶活性之间存在显著正相关（r = 0.97），血液硫胺素水平和/或红细胞转酮醇酶活性与红细胞TPP效应之间存在显著负相关（r = -0.525，r = -0.576）。在24例接受硫胺素治疗的糖尿病门诊患者中，包括14名男性和10名女性，排除1例（621.7 ng/ml）后血液硫胺素水平为96.5±44.5 ng/ml/小时，所有病例中83%高于正常下限。红细胞转酮醇酶活性为513.9±133.4微克/毫升/小时，58.3%高于正常下限。红细胞TPP效应为5.84±8.39%。血液硫胺素水平与红细胞转酮醇酶活性之间也存在显著正相关（r = 0.663），血液硫胺素水平和/或红细胞转酮醇酶活性与红细胞TPP效应之间存在显著负相关（r = 0.0668，r = 0.834）。接受硫胺素治疗的糖尿病门诊患者的血液硫胺素水平和红细胞转酮醇酶活性显著高于未接受硫胺素治疗的糖尿病门诊患者，而接受硫胺素治疗的糖尿病门诊患者的红细胞TPP效应显著低于未接受硫胺素治疗的糖尿病门诊患者。髌腱反射反应降低与硫胺素的生化状态之间没有直接关系。从上述发现得出结论，糖尿病门诊患者往往血液硫胺素水平较低，红细胞转酮醇酶活性较低且红细胞TPP效应较高，表现为边缘性硫胺素缺乏。
