26715Chungnam National University Hospital, Daejeon, Republic of Korea.
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211039129. doi: 10.1177/15330338211039129.
Neoadjuvant chemotherapy (NAC) is known to be a suitable treatment and first-line defense for locally advanced breast cancer. However, the NAC response may include unexpected outcomes, and it is not easy to predict the NAC response precisely. Especially, early detection of those patients who do not benefit from NAC is needed to reduce unnecessary therapy and side effects. The purpose of this study was to determine whether the pretreatment apparent diffusion coefficient (ADC) value is effective for predicting the response of breast cancer to NAC. Forty-nine breast cancer cases with pre- and post-NAC breast MRI were enrolled. MRI was performed using a 1.5-T scanner with the basic protocol including diffusion-weighted imaging. ADC difference value (ADC-diff) was calculated in all cases. ADC-diff was high in complete response and partial response cases ( < .05). ADC-diff correlated with the DWI rim sign, with a positive DWI rim sign being associated with a higher ADC-diff ( < .05). High-ADC difference value on the pretreatment MRI can provide information for a better response of NAC on breast cancer.
新辅助化疗（NAC）被认为是局部晚期乳腺癌的一种合适的治疗方法和一线防御手段。然而，NAC 的反应可能包括意想不到的结果，并且不容易准确预测 NAC 的反应。特别是，需要早期发现那些不能从 NAC 中获益的患者，以减少不必要的治疗和副作用。本研究旨在确定预处理表观扩散系数（ADC）值是否对预测乳腺癌对 NAC 的反应有效。共纳入 49 例接受 NAC 前后乳腺 MRI 的乳腺癌患者。MRI 采用 1.5-T 扫描仪进行，基本方案包括扩散加权成像。在所有病例中计算 ADC 差值（ADC-diff）。完全缓解和部分缓解病例的 ADC-diff 较高（<0.05）。ADC-diff 与 DWI 边缘征象相关，阳性 DWI 边缘征象与较高的 ADC-diff 相关（<0.05）。预处理 MRI 上的高 ADC 差值可提供有关乳腺癌 NAC 更好反应的信息。
