Feng Jinhui, Zhang Shitong, Chen Jiadong, Yang Jie, Zhu Jue
The Third Department of Gynecology, Ningbo Women & Children's Hospital, Ningbo, China.
Gynecol Endocrinol. 2021 Nov;37(11):1041-1045. doi: 10.1080/09513590.2021.1975675. Epub 2021 Sep 14.
Trends in the incidence of endometriosis in China remain unknown. The purpose of this study was to examine the trends in the incidence of endometriosis and the effects of age, period, and cohort on them.
Trends in endometriosis incidence were estimated using joinpoint regression. Age-period-cohort analysis was used to analyze the effects of age, period, and cohort on these trends. Endometriosis incidences in China (1990-2019) were retrieved from the Global Burden of Disease Study 2019. Annual percentage change and average annual percent change (AAPC) were analyzed by joinpoint regression, and relative risks were analyzed using an age-period-cohort model.
Age-standardized incidence rates (ASIRs) declined between 1990 and 2019 in China, with an overall AAPC of -1.2% (95% CI: -1.20, -1.10). Compared to 1990, the ASIR in 2019 decreased by almost 30%. Moreover, the joinpoint regression analysis revealed that endometriosis ASIRs showed a downward trend across all age groups. A significant age-related effect was seen for endometriosis incidence among young women aged 15-24 years, which then decreased with advancing age. Consistently, the effect of the period on endometriosis incidence showed a declining trend, and the effect of birth cohort decreased by 0.53 (42.7%) from 1938-1942 to 1998-2002.
Endometriosis ASIRs declined from 1990 to 2019. The effects of period and birth cohort on endometriosis incidence exhibited a declining trend across all age groups. The effect of age on endometriosis incidence showed an increasing trend before the age of 24, followed by a decreasing trend with subsequent advancing age.
中国子宫内膜异位症的发病率趋势尚不清楚。本研究的目的是探讨子宫内膜异位症发病率的趋势以及年龄、时期和队列对其的影响。
采用Joinpoint回归估计子宫内膜异位症发病率趋势。运用年龄-时期-队列分析来分析年龄、时期和队列对这些趋势的影响。从《2019年全球疾病负担研究》中获取中国（1990 - 2019年）的子宫内膜异位症发病率。通过Joinpoint回归分析年度百分比变化和平均年度百分比变化（AAPC），并使用年龄-时期-队列模型分析相对风险。
1990年至2019年中国年龄标准化发病率（ASIRs）呈下降趋势，总体AAPC为-1.2%（95%CI：-1.20，-1.10）。与1990年相比，2019年的ASIR下降了近30%。此外，Joinpoint回归分析显示，所有年龄组的子宫内膜异位症ASIRs均呈下降趋势。在15 - 24岁的年轻女性中，子宫内膜异位症发病率存在显著的年龄相关效应，随后随着年龄增长而下降。一致地，时期对子宫内膜异位症发病率的影响呈下降趋势，出生队列的影响从1938 - 1942年到1998 - 2002年下降了0.53（42.7%）。
1990年至2019年子宫内膜异位症ASIRs下降。时期和出生队列对子宫内膜异位症发病率的影响在所有年龄组中均呈下降趋势。年龄对子宫内膜异位症发病率的影响在24岁之前呈上升趋势，随后随着年龄增长呈下降趋势。
