Clinical evaluation of data-driven respiratory gating for PET/CT in an oncological cohort of 149 patients: impact on image quality and patient management.

OBJECTIVES

To evaluate the impact of fully automatic motion correction by data-driven respiratory gating (DDG) on positron emission tomography (PET) image quality, lesion detection and patient management.

MATERIALS AND METHODS

A total of 149 patients undergoing PET/CT for cancer (re-)staging were retrospectively included. Patients underwent a PET/CT on a digital detector scanner and for every patient a PET data set where DDG was enabled (PET) and as well as where DDG was not enabled (PET) was reconstructed. All PET data sets were evaluated by two readers which rated the general image quality, motion effects and organ contours. Further, both readers reviewed all scans on a case-by-case basis and evaluated the impact of PET on additional apparent lesion, change of report, and change of management.

RESULTS

In 85% ( = 126) of the patients, at least one bed position was acquired using DDG, resulting in mean scan time increase of 4:37 min per patient in the whole study cohort ( = 149). General image quality was not rated differently for PET and PET images ( = 1.000) while motion effects ( indicating general blurring) was rated significantly lower in PET images and organ contours, including liver and spleen, were rated significantly sharper using PET as compared to PET (all < 0.001). In 27% of patients, PET resulted in a change of the report and in a total of 12 cases (8%), PET resulted in a change of further clinical management.

CONCLUSION

Deviceless DDG provided reliable fully automatic motion correction in clinical routine and increased lesion detectability and changed management in a considerable number of patients.

ADVANCES IN KNOWLEDGE

DDG enables PET/CT with respiratory gating to be used routinely in clinical practice without external gating equipment needed.