Bassat Elad, Tanaka Elly M
Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter, 1030, Vienna, Austria.
Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter, 1030, Vienna, Austria.
Curr Opin Cell Biol. 2021 Dec;73:117-123. doi: 10.1016/j.ceb.2021.07.010. Epub 2021 Sep 11.
Limb amputation in salamanders yields a wound response that ultimately leads to replacement of the missing part. This unique-among-tetrapod trait involves the migration and recruitment of multiple cell types including epithelium, immune cells, axonal growth cones, and connective tissue cells to build the blastema which contains the proliferating stem and progenitor cells to rebuild the limb tissues. A number of the signaling and cell biological events have been defined. They point to the intimate coordination of physical events such as osmotic pressure, cell migration, and cell-cell communication with changes in cell identity such as dedifferentiation into embryonic-like epithelial and mesenchymal cells.
蝾螈的肢体截肢会引发一种伤口反应，最终导致缺失部分的替换。这种在四足动物中独一无二的特征涉及多种细胞类型的迁移和募集，包括上皮细胞、免疫细胞、轴突生长锥和结缔组织细胞，以构建芽基，芽基中含有增殖的干细胞和祖细胞来重建肢体组织。已经确定了许多信号传导和细胞生物学事件。它们表明物理事件如渗透压、细胞迁移和细胞间通讯与细胞身份变化如去分化为胚胎样上皮细胞和间充质细胞之间存在密切协调。
