LungenClinic, Großhansdorf.
Zentrum für Klinische Psychologie und Rehabilitation der Universität Bremen.
Pneumologie. 2022 Jan;76(1):25-34. doi: 10.1055/a-1579-7618. Epub 2021 Sep 14.
Quality of life (QoL) is significantly impaired in patients with pulmonary fibrosis, however reliable tools to assess QoL issues specific for this group of patients are still missing. We thus aimed to develop a new questionnaire called "Quality of life in patients with idiopathic pulmonary fibrosis" (QPF) to measure QoL in patients with fibrotic idiopathic interstitial pneumonias (IIP).
An item pool was created on the basis of a German expert group with support of patients suffering from pulmonary fibrosis. In a 1st step, this version of the questionnaire was completed by 52 patients with idiopathic pulmonary fibrosis (IPF) or non-specific interstitial pneumonia (NSIP). Following this, an item- and an exploratory factor analysis was carried out and a 2nd version created. In a multicenter validation study in a one-group pre-post design, the questionnaire was filled in by 200 patients with IIP (IPF = 190, iNSIP = 10) at 2 time points with an interval of 6 months. Cross-validation was carried out with the St. Georges Respiratory Questionnaire (SGRQ).
The mean age of the patients was 71.0 years (50-90 years), 82.5 % were male. Item analysis revealed that most of Cronbach alpha and selectivity values of QPF-scales could be considered as sufficient (e. g. QPF-scale "condition" [alpha = 0.827], "impairment" [alpha = 0.882]). At scale level, there were significant differences in terms of a deterioration or improvement in the QPF-condition and QPF-breathlessness scales and also in the SGRQ-activity scale. Analysis of construct validation of QPF and SGRQ showed moderate correlations between both questionnaires. A deterioration in health status from the patient's and doctor's perspective was seen in the scales "impairment", "shortness of breath" and "health status" of the QPF. The QPF was able to detect a change in the patient's mood ("condition" scale) in the course of treatment.
This newly developed questionnaire maps the special needs of the patients well. The QPF is suitable for screening of quality of life as well as for supplementing the medical history and for monitoring the course of disease in fibrotic IIPs.
肺纤维化患者的生活质量（QoL）显著受损，但仍缺乏专门针对这组患者的 QoL 评估工具。因此，我们旨在开发一种名为“特发性肺纤维化患者生活质量”（QPF）的新问卷，以测量纤维化特发性间质性肺疾病（IIP）患者的生活质量。
在德国专家组的支持下，基于患者的意见，创建了一个项目池。在第 1 步中，52 名特发性肺纤维化（IPF）或非特异性间质性肺炎（NSIP）患者填写了该问卷的初始版本。在此基础上，进行了项目和探索性因素分析，并创建了第 2 个版本。在一项多中心验证研究中，采用单组前后设计，200 名 IIP 患者（IPF=190，iNSIP=10）在 6 个月的间隔内分两次填写问卷。采用圣乔治呼吸问卷（SGRQ）进行交叉验证。
患者的平均年龄为 71.0 岁（50-90 岁），82.5%为男性。项目分析显示，QPF 量表的大多数 Cronbach alpha 和选择性值可被认为是足够的（例如，QPF 量表“条件”[alpha=0.827]，“损害”[alpha=0.882]）。在量表水平上，QPF 条件和 QPF 呼吸困难量表以及 SGRQ 活动量表的恶化或改善方面存在显著差异。QPF 和 SGRQ 的结构验证分析显示，两个问卷之间存在中度相关性。从患者和医生的角度来看，QPF 的“损害”、“呼吸困难”和“健康状况”等量表的健康状况恶化。QPF 能够在治疗过程中检测到患者情绪的变化（“条件”量表）。
新开发的问卷很好地满足了患者的特殊需求。QPF 适用于纤维化 IIP 患者的生活质量筛查，也可用于补充病史和监测疾病进程。
