Unidad de Gestión Clínica de Salud Pública, Prevención y Promoción de la Salud, Hospital de Valme, Área de Gestión Sanitaria Sur de Sevilla, Sevilla, Spain.
Departamento de Medicina Interna, Hospital Severo Ochoa, Leganés, Madrid, Spain.
Neurologia (Engl Ed). 2022 Sep;37(7):550-556. doi: 10.1016/j.nrleng.2019.06.007. Epub 2021 Sep 11.
To analyse the changes in stroke mortality trends in Spain by autonomous community and by sex during the period 1980-2016, using joinpoint regression models.
Mortality data were obtained from the Spanish National Statistics Institute. Crude and standardised rates were calculated for each Spanish autonomous community, and for each sex. Joinpoint analysis was used to identify the best-fitting points showing a statistically significant change in the trend.
Joinpoint analysis enabled us to differentiate between communities in which mortality rates showed a continuous decline throughout the study period in both sexes (Asturias, Cantabria, Castile and Leon, Ceuta, and Melilla) or in men only (Extremadura). In men, in all those communities in which changes in the trend were observed (all but Aragon, the Balearic Islands, and Murcia, where rates remained stable), we observed an initial period of decline (ranging from -3.4% in Catalonia and Extremadura, to -6.0% in Madrid) and a final period where the trends diverged: mortality rates continued to fall in Andalusia, Aragon, the Balearic Islands, and Madrid, but began to stabilise in Castile-La Mancha and Murcia and to increase in the Canary Islands. In women, in those communities where changes were observed (all but Aragon, Murcia, and the Basque Country, where rates remained stable), we observed an initial period of decline (ranging from -3.1% in Catalonia to -6.4% in Navarre) and a final period where divergent trends were observed: rates continued to decline in Andalusia, Aragon, Catalonia, Galicia, Madrid, and the Basque Country, but began to stabilise in Extremadura and Murcia and to increase in the Canary Islands.
Current data show that stroke mortality rates have decreased (in women in Andalusia), stabilised (in both sexes in Murcia, in men in Castile-La Mancha, and in women in Extremadura), and have even reversed (in both sexes in the Canary Islands). Further study is needed to identify the causes of these trends.
使用 joinpoint 回归模型分析 1980 年至 2016 年期间西班牙各自治区和性别间卒中死亡率趋势的变化。
从西班牙国家统计局获取死亡率数据。为每个西班牙自治区和性别计算了粗死亡率和标化死亡率。使用 joinpoint 分析确定最佳拟合点,以显示趋势的统计学显著变化。
joinpoint 分析使我们能够区分在研究期间两性死亡率持续下降的社区(阿斯图里亚斯、坎塔布里亚、卡斯蒂利亚-莱昂、休达和梅利利亚)或仅在男性中下降的社区(埃斯特雷马杜拉)。在男性中,在观察到趋势变化的所有社区(除了保持稳定的阿拉贡、巴利阿里群岛和穆尔西亚外),我们观察到一个初始下降期(范围从加泰罗尼亚和埃斯特雷马杜拉的-3.4%到马德里的-6.0%),最后趋势出现分歧:死亡率继续在安达卢西亚、阿拉贡、巴利阿里群岛和马德里下降,但在卡斯蒂利亚-拉曼恰和穆尔西亚开始稳定,并在加那利群岛上升。在女性中,在观察到变化的社区(除了保持稳定的阿拉贡、穆尔西亚和巴斯克地区外),我们观察到一个初始下降期(范围从加泰罗尼亚的-3.1%到纳瓦拉的-6.4%),最后趋势出现分歧:在安达卢西亚、阿拉贡、加泰罗尼亚、加利西亚、马德里和巴斯克地区,死亡率继续下降,但在埃斯特雷马杜拉和穆尔西亚开始稳定,并在加那利群岛上升。
目前的数据显示,卒中死亡率(在安达卢西亚的女性中)下降,(在穆尔西亚的两性中、在卡斯蒂利亚-拉曼恰的男性中和在埃斯特雷马杜拉的女性中)稳定,甚至(在加那利群岛的两性中)逆转。需要进一步研究以确定这些趋势的原因。