Fenaux P, Huart J J, Mannessier L, Caulier M T, Zandecki M, Jouet J P, Bauters F
Service des Maladies du Sang, Hôpital Huriez, CHU Lille, France.
Nouv Rev Fr Hematol (1978). 1987;29(6):383-6.
We report on a 74-year-old male patient who presented with jaundice, highly increased unconjugated bilirubin and slight nonregenerative anemia. Ferrokinetic studies demonstrated ineffective erythropoiesis and red cell survival, studied by 51 Cr, showed moderately increased hemolysis. Other findings showed no evidence of an underlying myelodysplastic syndrome but strongly favored the autoimmune origin of the disorder, with immunologic destruction of erythroblasts (and to a far lesser extent erythrocytes) by autoantibodies.
我们报告了一名74岁男性患者，该患者出现黄疸、非结合胆红素显著升高及轻度非再生性贫血。铁动力学研究显示红细胞生成无效，通过51 Cr研究的红细胞存活情况显示溶血程度中度增加。其他检查结果未发现潜在骨髓增生异常综合征的证据，但强烈提示该疾病的自身免疫起源，即自身抗体对成红细胞（以及程度较轻的红细胞）进行免疫破坏。
