Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Hubei Key Laboratory of Molecular Imaging, Wuhan, 430022, China.
Theranostics. 2021 Sep 3;11(18):9177-9179. doi: 10.7150/thno.66417. eCollection 2021.
Ideal nuclear imaging tracers should exhibit high target uptake and low background signal. Traditional renal scintigraphy and SPECT scans examine kidney function static or dynamic tracing of radioactive probes in the kidneys. The lack of tracer affinity to specific biological processes and high background uptake from urinary excretion have added many difficulties to precision renal diagnosis. In this issue of , Jin and colleagues innovatively devised a recombinant probe for preferential kidney imaging through targeting of tubular neonatal Fc receptor and proximal tubular basement membrane for sustained tubular reabsorption and accumulation. This work has broad implications regarding how an in depth understanding of physiology and pathology may be of service for tracer development, renal diagnosis, and disease theranostics.
理想的核医学成像示踪剂应具有高靶摄取和低背景信号的特点。传统的肾闪烁扫描和 SPECT 扫描通过对肾脏中放射性探针的静态或动态追踪来检查肾脏功能。由于缺乏对特定生物过程的示踪亲和力以及从尿液排泄中摄取的高背景，给精确的肾脏诊断带来了许多困难。在本期《自然》杂志中，Jin 及其同事通过靶向管状新生儿 Fc 受体和近端肾小管基底膜，设计了一种新型重组探针，用于选择性的肾脏成像，探针可通过持续的管状重吸收和积累在肾脏中蓄积。这项工作对于深入了解生理学和病理学如何为示踪剂开发、肾脏诊断和疾病治疗提供服务具有广泛的意义。
