他汀类药物作为抗细胞焦亡剂。
Statins as anti-pyroptotic agents.
作者信息
Khalifeh Masoomeh, Penson Peter E, Banach Maciej, Sahebkar Amirhossein
机构信息
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
出版信息
Arch Med Sci. 2021 Aug 9;17(5):1414-1417. doi: 10.5114/aoms/141155. eCollection 2021.
INTRODUCTION
Pyroptosis is a regulated form of cell death, which is often a consequence of the activation of inflammatory caspases.
METHODS
Appropriate inflammatory responses and the induction of pyroptosis enhance the clearance of pathogens and increase innate immunity.
RESULTS
However, excessive pyroptosis contributes to a hyperinflammatory response and aggravates tissue damage, thereby causing inflammatory diseases. There have been recent reports on the modulation of pyroptosis by statins, which may explain part of the pleiotropic actions of these drugs in inflammatory diseases and cancer.
CONCLUSIONS
Herein, the extant evidence for the potential value of statins in targeting pyroptosis in various diseases is reviewed.
引言
细胞焦亡是一种受调控的细胞死亡形式，通常是炎性半胱天冬酶激活的结果。
方法
适当的炎症反应和细胞焦亡的诱导可增强病原体的清除并提高先天免疫力。
结果
然而，过度的细胞焦亡会导致炎症反应过度并加重组织损伤，从而引发炎症性疾病。最近有关于他汀类药物对细胞焦亡调节作用的报道，这可能解释了这些药物在炎症性疾病和癌症中的部分多效性作用。
结论
本文综述了他汀类药物在针对各种疾病中的细胞焦亡方面潜在价值的现有证据。
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