Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Pharmacol Res. 2018 Sep;135:230-238. doi: 10.1016/j.phrs.2018.08.014. Epub 2018 Aug 16.
The toll-like receptors (TLRs) are a class of transmembrane-spanning receptors that are sentinels of both innate and adaptive immunity. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the most commonly prescribed therapeutic agents for treating hypercholesterolemia globally. However, statin therapy appears to have pleiotropic effects including attenuation of chronic low-grade inflammation and modulation of TLR activity. Statins through abolition of TLR4 expression and regulation of the TLR4/Myd88/NF-κB signaling pathway may slow the progression of atherosclerosis and other inflammatory diseases. In this review, we have focused on the impact and mechanism of action of statins on cardiovascular and non-cardiovascular diseases.
toll 样受体（TLRs）是一类跨膜受体，是先天免疫和适应性免疫的哨兵。他汀类药物（3-羟基-3-甲基戊二酰辅酶 A 还原酶抑制剂）是目前全球治疗高胆固醇血症最常用的治疗药物。然而，他汀类药物似乎具有多种作用，包括减轻慢性低度炎症和调节 TLR 活性。他汀类药物通过消除 TLR4 表达和调节 TLR4/Myd88/NF-κB 信号通路，可能减缓动脉粥样硬化和其他炎症性疾病的进展。在这篇综述中，我们重点讨论了他汀类药物对心血管和非心血管疾病的影响及其作用机制。
