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Mechanism of tangshen formula in treating diabetic nephropathy revealed by network pharmacology approach.

作者信息

Quan Na, Guo Junfu

机构信息

ZhuHai Health School, Zhuhai, Guangdong Province, China.

Cherbtop Chinese Medicine Technology Development Co. Ltd. of Guangdong, Zhuhai, Guangdong Province, China.

出版信息

Arch Med Sci. 2021 Aug 10;17(5):1436-1439. doi: 10.5114/aoms/140544. eCollection 2021.

DOI:10.5114/aoms/140544
PMID:34522276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8425243/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f67/8425243/fe82b03e8cef/AMS-17-5-140544-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f67/8425243/fe82b03e8cef/AMS-17-5-140544-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f67/8425243/fe82b03e8cef/AMS-17-5-140544-g001.jpg

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Mechanism of tangshen formula in treating diabetic nephropathy revealed by network pharmacology approach.基于网络药理学方法揭示党参方治疗糖尿病肾病的机制
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2
Evidence for the involvement of JAK/STAT/SOCS pathway in the mechanism of Tangshen formula-treated diabetic nephropathy.JAK/STAT/SOCS信号通路参与糖肾方治疗糖尿病肾病机制的证据。
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[Effect of tangshen formula on phospholipids metabolism in diabetic nephropathy patients].[糖肾方对糖尿病肾病患者磷脂代谢的影响]
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Tangshen Formula Attenuates Diabetic Nephropathy by Promoting ABCA1-Mediated Renal Cholesterol Efflux in db/db Mice.糖肾方通过促进ABCA1介导的db/db小鼠肾胆固醇外流减轻糖尿病肾病
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Effects of Tangshen Formula on urinary and plasma liver-type fatty acid binding protein levels in patients with type 2 diabetic kidney disease: post-hoc findings from a multi-center, randomized, double-blind, placebo-controlled trial investigating the efficacy and safety of Tangshen Formula in patients with type 2 diabetic kidney disease.糖肾方对2型糖尿病肾病患者尿和血浆肝型脂肪酸结合蛋白水平的影响：一项多中心、随机、双盲、安慰剂对照试验的事后分析结果，该试验旨在研究糖肾方治疗2型糖尿病肾病患者的疗效和安全性。
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本文引用的文献

1
Chronic kidney disease in type 2 diabetes: Implications for managing glycaemic control, cardiovascular and renal risk.2型糖尿病中的慢性肾脏病：对血糖控制、心血管及肾脏风险管理的意义
Diabetes Obes Metab. 2020 Apr;22 Suppl 1:32-45. doi: 10.1111/dom.13942.
2
Adiponectin improves diabetic nephropathy by inhibiting necrotic apoptosis.脂联素通过抑制坏死性凋亡改善糖尿病肾病。
Arch Med Sci. 2019 Sep;15(5):1321-1328. doi: 10.5114/aoms.2018.79570. Epub 2018 Nov 13.
3
Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus.
糖尿病所致慢性肾脏病中内脂素和内皮糖蛋白水平的评估。
Arch Med Sci. 2019 Jan;15(1):86-91. doi: 10.5114/aoms.2018.79488. Epub 2018 Nov 14.
4
Involvement of the TGFβ1- ILK-Akt signaling pathway in the effects of hesperidin in type 2 diabetic nephropathy.橙皮苷在 2 型糖尿病肾病中的作用涉及 TGFβ1-ILK-Akt 信号通路。
Biomed Pharmacother. 2018 Sep;105:766-772. doi: 10.1016/j.biopha.2018.06.036. Epub 2018 Jun 14.
5
Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.糖尿病肾病中代谢基因改变的原因是 pregnane X 受体的异常 DNA 甲基化。
Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F551-F560. doi: 10.1152/ajprenal.00390.2017. Epub 2017 Dec 6.
6
Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in streptozotocin-induced diabetic rats.橙皮素，一种柑橘类黄酮，具有降血糖作用，可减轻高血糖，并探讨其在链脲佐菌素诱导的糖尿病大鼠中的抗氧化和抗高血脂作用。
Biomed Pharmacother. 2018 Jan;97:98-106. doi: 10.1016/j.biopha.2017.10.102. Epub 2017 Nov 6.
7
Merkel disc is a serotonergic synapse in the epidermis for transmitting tactile signals in mammals.默克尔盘是哺乳动物表皮中用于传递触觉信号的5-羟色胺能突触。
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5491-500. doi: 10.1073/pnas.1610176113. Epub 2016 Aug 29.
8
Effects of Tangshen Formula on urinary and plasma liver-type fatty acid binding protein levels in patients with type 2 diabetic kidney disease: post-hoc findings from a multi-center, randomized, double-blind, placebo-controlled trial investigating the efficacy and safety of Tangshen Formula in patients with type 2 diabetic kidney disease.糖肾方对2型糖尿病肾病患者尿和血浆肝型脂肪酸结合蛋白水平的影响：一项多中心、随机、双盲、安慰剂对照试验的事后分析结果，该试验旨在研究糖肾方治疗2型糖尿病肾病患者的疗效和安全性。
BMC Complement Altern Med. 2016 Jul 26;16:246. doi: 10.1186/s12906-016-1228-4.
9
The relationship between neutrophil-to-lymphocyte ratio and albuminuria in type 2 diabetic patients: a pilot study.2型糖尿病患者中性粒细胞与淋巴细胞比值和蛋白尿之间的关系：一项初步研究。
Arch Med Sci. 2016 Jun 1;12(3):571-5. doi: 10.5114/aoms.2016.59931. Epub 2016 May 18.
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The Incidence of End-Stage Renal Disease in the Diabetic (Compared to the Non-Diabetic) Population: A Systematic Review.糖尿病（与非糖尿病相比）人群中终末期肾病的发病率：一项系统评价。
PLoS One. 2016 Jan 26;11(1):e0147329. doi: 10.1371/journal.pone.0147329. eCollection 2016.