Liu Wentan, Ke Jie, He Chuan
Shenzhen Grubbs Institute, Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology Shenzhen Guangdong 518055 China
Chem Sci. 2021 Jul 7;12(33):10972-10984. doi: 10.1039/d1sc02614c. eCollection 2021 Aug 25.
Transition-metal-catalyzed enantioselective C-H functionalization has emerged as a powerful tool for the synthesis of enantioenriched compounds in chemical and pharmaceutical industries. Sulfur-based functionalities are ubiquitous in many of the biologically active compounds, medicinal agents, functional materials, chiral auxiliaries and ligands. This perspective highlights recent advances in sulfur functional group enabled transition-metal-catalyzed enantioselective C-H functionalization for the construction of sulfur stereogenic centers, as well as the utilization of chiral sulfoxides to realize stereoselective C-H functionalization.
过渡金属催化的对映选择性C-H官能化已成为化学和制药工业中合成对映体富集化合物的有力工具。含硫官能团广泛存在于许多生物活性化合物、药物、功能材料、手性助剂和配体中。本文综述了基于硫官能团的过渡金属催化对映选择性C-H官能化在构建硫立体中心方面的最新进展，以及利用手性亚砜实现立体选择性C-H官能化的研究进展。
