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[急性弥漫性腹膜炎内毒素血症病因中的脂质过氧化及其血液吸附纠正的可能性]

[Lipid peroxidation in the etiology of endotoxemia in acute diffuse peritonitis and the possibility of its correction by hemosorption].

作者信息

Eriukhin I A, Belyĭ V Ia, Khanevich M D, Tupikova Z A, Vagner V K

出版信息

Vestn Khir Im I I Grek. 1987 Oct;139(10):104-9.

PMID:3452245
Abstract

The state of lipid peroxidation (LP) was studied in 65 patients with acute diffuse peritonitis at different phases of its development as well as the effect of hemosorption on the concentration of LP products in blood serum and its antioxidant activity. It was established that patients with diffuse peritonitis have considerably activated LP. The LP products when getting into the general blood flow play a substantial role in the formation of endogenous intoxication syndrome. The inclusion of hemosorption in the detoxication therapy complex leads to markedly decreased amount of peroxidation products in blood serum.

摘要

研究了65例急性弥漫性腹膜炎患者在疾病发展不同阶段的脂质过氧化(LP)状态,以及血液吸附对血清中LP产物浓度及其抗氧化活性的影响。结果表明,弥漫性腹膜炎患者的LP显著激活。LP产物进入全身血流时,在内源性中毒综合征的形成中起重要作用。在解毒治疗方案中加入血液吸附可使血清中过氧化产物的量显著减少。

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