Kawasaki Yoichi, Sendo Toshiaki
Department of Pharmacy, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Curr Res Toxicol. 2021 Aug 27;2:322-328. doi: 10.1016/j.crtox.2021.08.004. eCollection 2021.
Photoinitiators are utilized in the production of a wide range of commonly used products. However, some photoinitiators exert toxic effects. We previously demonstrated the endocrine-disrupting effects of photoinitiators . The present study investigated the estrogenic activities of three photoinitiators: 1-hydroxycyclohexyl phenyl ketone (1-HCHPK), methyl 2-benzoylbenzoate (MBB), and 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MTMP), which were subcutaneously injected into mouse xenografts with MCF-7 breast cancer cells. The results obtained showed that 1-HCHPK, MBB, and MTMP promoted breast tumor growth in these xenografts. A pretreatment with the estrogen receptor antagonist tamoxifen blocked the tumor growth-promoting effects of each photoinitiator. Collectively, the present results suggest that the three photoinitiators exhibit estrogenic agonist activities . Furthermore, as a factor for breast tumor growth, these photoinitiators potentially have estrogenic properties .
光引发剂被用于生产多种常用产品。然而，一些光引发剂会产生毒性作用。我们之前已证明光引发剂具有内分泌干扰作用。本研究调查了三种光引发剂的雌激素活性：1-羟基环己基苯基酮（1-HCHPK）、2-苯甲酰苯甲酸甲酯（MBB）和2-甲基-4'-（甲硫基）-2-吗啉代苯丙酮（MTMP），它们被皮下注射到携带MCF-7乳腺癌细胞的小鼠异种移植瘤中。所得结果表明，1-HCHPK、MBB和MTMP促进了这些异种移植瘤中的乳腺肿瘤生长。用雌激素受体拮抗剂他莫昔芬进行预处理可阻断每种光引发剂的肿瘤生长促进作用。总体而言，目前的结果表明这三种光引发剂具有雌激素激动剂活性。此外，作为乳腺肿瘤生长的一个因素，这些光引发剂可能具有雌激素特性。
