Barnard Mollie E, Boeke Caroline E, Tamimi Rulla M
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA.
Biochim Biophys Acta. 2015 Aug;1856(1):73-85. doi: 10.1016/j.bbcan.2015.06.002. Epub 2015 Jun 10.
Breast cancer is a heterogeneous disease with multiple intrinsic tumor subtypes. These subtypes vary in tumor gene expression and phenotype, and are most commonly grouped into four major subtypes: luminal A, luminal B, HER2-overexpressing and triple negative (or basal-like). A growing number of studies have evaluated the relationship between established breast cancer risk factors and risk of one or more intrinsic tumor subtypes. We conducted a systematic review of 38 studies to synthesize their results and identify areas requiring more research. Taken together, published studies suggest that most established breast cancer risk factors reflect risk factors for the luminal A subtype of breast cancer, and some breast cancer risk factors may be differentially associated with other intrinsic tumor subtypes. Future breast cancer research will need to consider etiologic differences across subtypes and design studies focused on understanding the etiology and prevention of less common tumor subtypes.
乳腺癌是一种具有多种内在肿瘤亚型的异质性疾病。这些亚型在肿瘤基因表达和表型方面存在差异，最常见的分为四种主要亚型：腔面A型、腔面B型、HER2过表达型和三阴性（或基底样型）。越来越多的研究评估了既定乳腺癌风险因素与一种或多种内在肿瘤亚型风险之间的关系。我们对38项研究进行了系统综述，以综合其结果并确定需要更多研究的领域。综合来看，已发表的研究表明，大多数既定的乳腺癌风险因素反映了乳腺癌腔面A型的风险因素，并且一些乳腺癌风险因素可能与其他内在肿瘤亚型存在差异关联。未来的乳腺癌研究需要考虑各亚型之间的病因差异，并设计专注于了解较不常见肿瘤亚型的病因和预防的研究。
