Barret L, Garrel S, Danel V, Debru J L
Department of Toxicology, CHU Grenoble, France.
Arch Environ Health. 1987 Sep-Oct;42(5):297-302. doi: 10.1080/00039896.1987.9935824.
Trigeminal nerve impairment is frequently seen in chronic trichlorethylene intoxication (TRI). A total of 104 occupationally exposed subjects were selected for study because they were employed at a highly exposed workplace. They were studied by clinical examination and by trigeminal somatosensory evoked potentials (TSEP). Normal values for TSEP were obtained from the study of 52 healthy nonexposed subjects. Facial hypoesthesia, when present, was global and predominant in the mandibular and maxillary nerve areas, associated or not with absent reflexes. A disturbed TSEP was found in 40 subjects which was predictable from their clinical symptoms. Correlation with exposure parameters (duration of exposure, trichlorethanol, and trichloracetic acid urinary rates) was mainly observed in subjects presenting both clinical and electrical alterations. Electrical alterations alone were less predictive. An abnormal TSEP may thus provide objective determination of risk assessment in the absence of clinical signs.
三叉神经损伤在慢性三氯乙烯中毒（TRI）中较为常见。共有104名职业暴露受试者被选入研究，因为他们受雇于高暴露工作场所。通过临床检查和三叉神经体感诱发电位（TSEP）对他们进行了研究。TSEP的正常值来自于对52名健康非暴露受试者的研究。面部感觉减退若存在，则为全身性，以下颌神经和上颌神经区域为主，可伴有或不伴有反射消失。40名受试者的TSEP出现异常，这可根据他们的临床症状预测。与暴露参数（暴露持续时间、三氯乙醇和三氯乙酸尿排泄率）的相关性主要见于同时出现临床和电生理改变的受试者。仅电生理改变的预测性较低。因此，在没有临床体征的情况下，TSEP异常可为风险评估提供客观依据。
