Barret L, Arsac P, Vincent M, Faure J, Garrel S, Reymond F
J Toxicol Clin Toxicol. 1982 Jun;19(4):419-23. doi: 10.3109/15563658208992496.
Results of a study of trigeminal nerve impairment resulting from trichloroethylene intoxication by the somatosensory-evoked potential method reveal three kinds of abnormalities: increased stimulation voltage, excessive latency delay with morphological abnormalities, and excessive graph amplitude. These abnormalities confirm clinical disturbance (hypesthesia of the trigeminal nerve area) and open debate about the real mechanism of trichloroethylene neurotoxicity. Industrial intoxication by solvents, particularly trichloroethylene, is common. We have conducted a study of 188 workers chronically exposed to trichloroethylene and have confirmed the selective neurological disturbances of this intoxication in the trigeminal nerve (20%) [3, 10]. We utilized a new experimental method, developed for studies of chronic intoxications effecting the median nerve [5, 8], of recording the somatosensory evoked potential following stimulation of the trigeminal nerve [4, 6, 7]. The workers in this study were selected following clinical evaluation of their facial sensitivity and trigeminal nerve reflexes. In this paper we present our preliminary results on 11 workers, 9 suffering effects of intoxication and 2 controls.
刺激电压升高、潜伏期过度延长且伴有形态异常、图形波幅过高。这些异常证实了临床症状（三叉神经区域感觉减退），并引发了关于三氯乙烯神经毒性真正机制的讨论。溶剂中毒，尤其是三氯乙烯中毒，在工业领域很常见。我们对188名长期接触三氯乙烯的工人进行了研究，证实了这种中毒在三叉神经方面存在选择性神经功能障碍（20%）[3, 10]。我们采用了一种新的实验方法，该方法是为研究影响正中神经的慢性中毒而开发的[5, 8]，用于记录刺激三叉神经后的体感诱发电位[4, 6, 7]。本研究中的工人是在对其面部敏感性和三叉神经反射进行临床评估后挑选出来的。在本文中，我们展示了对11名工人的初步研究结果，其中9名受中毒影响，2名作为对照。
