Garrel S, Barret L
Rev Electroencephalogr Neurophysiol Clin. 1986 Jul;16(2):133-9. doi: 10.1016/s0370-4475(86)80005-3.
Industrial intoxication by trichloroethylene can produce neurological disturbance of the trigeminal nerve. Therefore, among 105 workers exposed to this toxin, we recorded cortical responses after stimulation of the trigeminal nerve (TSEP) and we compared our results with a control group of 52 subjects. We considered the physical examination exploring, the facial sensitivity and reflexes, the levels of urinary metabolites of trichloroethylene and TSEP. We can describe 4 groups of workers: group A, 13 subjects with perturbations of clinical and evoked responses; group B, 27 subjects with normal physical examination though with disturbed TSEP; group C, 6 subjects had an abnormal examination though evoked responses were normal; group D, 59 subjects had normal clinical examination and TSEP. Disturbed TSEP (particularly delayed responses) are found among the older workers with the longest duration of exposure and higher level of exposure. The alteration of TSEP may appear before clinical disturbance. TSEP could represent a useful test for the supervision of the exposed workers and the clinical diagnosis of the trigeminal impairment.
三氯乙烯中毒可导致三叉神经的神经功能紊乱。因此，我们对105名接触该毒素的工人进行了研究，记录了刺激三叉神经后的皮层反应（三叉神经体感诱发电位，TSEP），并将结果与52名对照组受试者进行了比较。我们综合考虑了体格检查、面部感觉和反射、三氯乙烯尿代谢物水平以及TSEP。我们将工人分为4组：A组，13名临床和诱发反应均有异常的受试者；B组，27名体格检查正常但TSEP异常的受试者；C组，6名检查异常但诱发反应正常的受试者；D组，59名临床检查和TSEP均正常的受试者。在接触时间最长、接触水平较高的年长工人中发现TSEP异常（尤其是反应延迟）。TSEP的改变可能出现在临床症状之前。TSEP可作为监测接触工人和三叉神经损伤临床诊断的有用检测方法。
