Wang Long, Wu Jun-Cang, Wang Fu-Yu, Chen Xin, Wang Yu
Department of Neurology, The Second People's Hospital of Hefei, Hefei, China.
Department of Pharmacy, The Second People's Hospital of Hefei, Hefei, China.
Acta Neurol Scand. 2022 Jan;145(1):87-93. doi: 10.1111/ane.13528. Epub 2021 Sep 15.
The association between migraine and dementia has rarely been investigated, and available results are conflicting. Thus, the aim of this meta-analysis was to evaluate whether an association exists between migraine and dementia.
MATERIALS & METHODS: We searched for cohort studies from databases including PubMed, EBSCO, Web of Science, and EMBASE database from inception to April 1, 2021, using subject and free words. RevMan 5.1 software was used to calculate the risk ratio (RR) of dementia in patients with migraine. Subgroup and sensitivity analyses were conducted to assess the source of heterogeneity. A random-effects model was used when heterogeneity was present. The Funnel plot and Egger's test were used to evaluate publication bias.
Five published cohort studies covering a total of 249,303 individuals were identified. Pooled analysis showed that migraine was associated with increased risk of all-cause dementia (RR: 1.34, 95% CI: 1.13-1.59) and Alzheimer's disease (AD) (RR: 2.49, 95% CI: 1.16-5.32). However, we did not found any association between migraine and risk of vascular dementia (VaD) (RR: 1.51, 95% CI: 0.77-2.96).
Our results revealed that migraine was a potential risk indicator for AD and all-cause dementia.
偏头痛与痴呆症之间的关联鲜有研究，现有结果相互矛盾。因此，本荟萃分析的目的是评估偏头痛与痴呆症之间是否存在关联。
我们使用主题词和自由词，在包括PubMed、EBSCO、科学网和EMBASE数据库在内的数据库中检索自数据库建立至2021年4月1日的队列研究。使用RevMan 5.1软件计算偏头痛患者患痴呆症的风险比（RR）。进行亚组分析和敏感性分析以评估异质性来源。当存在异质性时，使用随机效应模型。采用漏斗图和Egger检验评估发表偏倚。
共识别出5项已发表的队列研究，涉及249,303名个体。汇总分析表明，偏头痛与全因痴呆症（RR：1.34，95%CI：1.13 - 1.59）和阿尔茨海默病（AD）（RR：2.49，95%CI：1.16 - 5.32）风险增加相关。然而，我们未发现偏头痛与血管性痴呆（VaD）风险之间存在任何关联（RR：1.51，95%CI：0.77 - 2.96）。
我们的结果表明，偏头痛是AD和全因痴呆症的潜在风险指标。
