Electrochemical Oxidative Difunctionalization of Alkenes to Access α-Oxygenated Ketones.
作者信息
Dai Changhui, Shen Yijie, Wei Yifan, Liu Ping, Sun Peipei
机构信息
School of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.
出版信息
J Org Chem. 2021 Oct 1;86(19):13711-13719. doi: 10.1021/acs.joc.1c01831. Epub 2021 Sep 15.
Dioxygenation of alkenes was developed by the combination of electrochemical synthesis and aerobic oxidation, leading to easy accessibility of α-oxygenated ketones in an eco-friendly fashion. Using air as the oxygen source and the absence of transition metals were the critical features of this protocol. A wide range of alkenes and hydroxyimides were found to be compatible and provided α-oxygenated ketones in moderate to high yields.
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