重症肌无力患者胸腺中的类固醇受体。

Steroid receptors in the myasthenic thymus.

作者信息

Brentani M M, Martins V R, Marchiori P E

机构信息

Departamento de Clínica Médica, Faculdade de Medicina, Universidade de São Paulo, Brasil.

出版信息

Braz J Med Biol Res. 1987;20(5):569-72.

PMID:3452447

Abstract

Estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid receptors (GR) were evaluated in thymus cytosols from 15 myasthenia gravis (MG) patients, using a dextran charcoal assay. ER was found in 40%, PR and AR in 53% and GR in 100% of MG thymi. Competition studies demonstrated steroid specificity for all receptors. Mean ER and AR levels in MG thymi were higher than those in the thymi of 4 control children. Female patients have higher AR titers. Myasthenic thymi presented lower GR values than in normal controls: Differences in steroid receptor content observed in the MG thymus as compared to the child thymus may reflect variations in cell populations.

摘要

采用葡聚糖活性炭分析法，对15例重症肌无力（MG）患者胸腺胞质溶胶中的雌激素受体（ER）、孕激素受体（PR）、雄激素受体（AR）和糖皮质激素受体（GR）进行了评估。在40%的MG胸腺中发现了ER，53%的MG胸腺中发现了PR和AR，100%的MG胸腺中发现了GR。竞争研究表明所有受体都具有类固醇特异性。MG胸腺中ER和AR的平均水平高于4名对照儿童胸腺中的水平。女性患者的AR滴度更高。重症肌无力胸腺的GR值低于正常对照：与儿童胸腺相比，MG胸腺中观察到的类固醇受体含量差异可能反映了细胞群体的变化。