Teixeira H C, Calich V L, Singer-Vermes L M, D'Imperio-Lima M R, Russo M
Departamento de Imunologia, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1987;20(5):587-9.
The course of Paracoccidioides brasiliensis infection depends on the natural resistance of the host and on the virulence of the fungus isolate. In the present study the immune response to sheep red blood cells (SRBC) was investigated in susceptible (B10.A) and resistant (A/SN) mice after intraperitoneal (ip) infection with pathogenic (Pb18) and apathogenic (IVIC Pb267) P. brasiliensis isolates. Infection with Pb18 yeast cells quickly induces a state of immunodepression only in the susceptible mice. This immunosuppression was not observed when mice were inoculated with IVIC Pb267 yeast.
巴西副球孢子菌感染的病程取决于宿主的天然抵抗力以及真菌分离株的毒力。在本研究中，对易感（B10.A）和抗性（A/SN）小鼠腹腔内（ip）感染致病性（Pb18）和非致病性（IVIC Pb267）巴西副球孢子菌分离株后，研究了其对绵羊红细胞（SRBC）的免疫反应。仅在易感小鼠中，Pb18酵母细胞感染迅速诱导免疫抑制状态。当小鼠接种IVIC Pb267酵母时，未观察到这种免疫抑制现象。
