Centre for Chromosome Biology, National University of Ireland, Galway, Ireland; Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
Cell Rep. 2021 Sep 14;36(11):109736. doi: 10.1016/j.celrep.2021.109736.
The DNA repair proteins FAN1 and MLH1 have opposing effects on triplet repeat expansions. New studies by Goold et al. (2021) and Porro et al. (2021) pinpoint interactions between FAN1 and MLH1 that cross-regulate each other's activities.
DNA 修复蛋白 FAN1 和 MLH1 对三核苷酸重复扩展有相反的影响。Goold 等人(2021 年)和 Porro 等人(2021 年)的新研究指出了 FAN1 和 MLH1 之间的相互作用,这些相互作用交叉调节彼此的活性。